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Articles Published Processes
3/21/2025 6:10:16 AM | Browse: 190 | Download: 938
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Received |
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2024-10-09 02:54 |
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Peer-Review Started |
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2024-10-09 02:54 |
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First Decision by Editorial Office Director |
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2025-01-09 02:41 |
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Return for Revision |
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2025-01-09 02:41 |
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Revised |
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2025-01-21 14:11 |
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Publication Fee Transferred |
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2025-01-24 11:24 |
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Second Decision by Editor |
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2025-02-21 08:24 |
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Second Decision by Editor-in-Chief |
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2025-02-25 20:10 |
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Final Decision by Editorial Office Director |
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2025-02-26 08:11 |
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Articles in Press |
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2025-02-26 08:11 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-03-13 09:07 |
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Publish the Manuscript Online |
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2025-03-21 06:10 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Developmental Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Mesenchymal stem cell exosomes enhance the development of hair follicle to ameliorate androgenetic alopecia
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Fu, Yao-Ting Han, Jun-Ling Xie, Rong-Qi Liu, Bo Zhao, Xing-Liao Zhang, Jun Zhang and Jing Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Peak Disciplines (Type IV) of Institutions of Higher Learning in Shanghai and the China Postdoctoral Science Foundation |
2022M722409 |
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| Corresponding Author |
Jing Zhang, PhD, Professor, Research Center for Translational Medicine at East Hospital, School of Life Science, Tongji University, No. 1239 Siping Road, Shanghai 200092, China. 96755@tongji.edu.cn |
| Key Words |
Mesenchymal stem cells; Exosome; Dermal papillary cells; Hair development; Liquid chromatography-mass spectrometry proteomic analysis |
| Core Tip |
Liquid chromatography-mass spectrometry proteomic analysis was conducted to reveal the commonalities and heterogeneities across the human adipose-derived mesenchymal stem cell exosomes (hADSC-Exos) and human umbilical cord-derived mesenchymal stem cell exosomes. A total of 232 common proteins were found in hADSC-Exos and were categorized into 10 functional groups. We have confirmed that hADSC-Exos decrease glycogen synthase kinase-3β expression through the Wnt/β-catenin pathway, leading to increased proliferation and migration of dermal papillary cell. Excessive dihydrotestosterone can cause hair loss by shortening the hair growth phase, but hADSC-Exo treatment can reverse this effect. This study suggests that hADSC-Exo plays a role in hair regeneration through cell-to-cell communication via the Wnt/β-catenin pathway. |
| Publish Date |
2025-03-21 06:10 |
| Citation |
Fu Y, Han YT, Xie JL, Liu RQ, Zhao B, Zhang XL, Zhang J, Zhang J. Mesenchymal stem cell exosomes enhance the development of hair follicle to ameliorate androgenetic alopecia. World J Stem Cells 2025; 17(3): 102088 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i3/102088.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i3.102088 |
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