Publication Name	World Journal of Orthopedics
Manuscript ID	102101
Country	China

Received	2024-10-08 14:21
Peer-Review Started	2024-10-08 14:21
To Make the First Decision
Return for Revision	2024-12-05 08:03
Revised	2024-12-18 13:32
Second Decision	2025-01-10 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-11 09:13
Articles in Press	2025-01-11 09:13
Publication Fee Transferred	2024-12-21 03:13
Edit the Manuscript by Language Editor	2025-01-17 01:37
Typeset the Manuscript	2025-02-06 05:33
Publish the Manuscript Online	2025-02-12 02:27

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Observational Study
Article Title	Novel association between chronic obstructive pulmonary disease and osteoporosis: A prospective cross-sectional study
Manuscript Source	Unsolicited Manuscript
All Author List	Rong Gao, Jian-Kang Zeng, Kai Yang, Ping Wang and Sheng Zhou
ORCID	Author(s) ORCID Number Rong Gao http://orcid.org/0009-0009-0669-9960 Jian-Kang Zeng http://orcid.org/0009-0002-4898-5577 Kai Yang http://orcid.org/0009-0001-7782-7062 Ping Wang http://orcid.org/0000-0002-9669-6246 Sheng Zhou http://orcid.org/0009-0004-1821-7272
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China (NSFC) of China 82360358 The Internal Medicine Research Project of Gansu Provincial People's Hospital 22GSSYD-77 Natural Science Foundation of Gansu Province 22JR5RA659
Corresponding Author	Sheng Zhou, MD, PhD, Professor, Department of Diagnostic Radiology, Gansu Provincial Hospital, No. 204 Donggang West Road, Lanzhou 730000, Gansu Province, China. lzzs@sina.com
Key Words	Chronic obstructive pulmonary disease; Osteoporosis; Bone mineral density; Lung function; Quantitative computed tomography; FEV1/FVC%
Core Tip	This study investigated the relationship between bone mineral density (BMD) and lung function, mainly the forced expiratory volume in the first second (FEV1) /forced vital capacity (FVC) %, in chronic obstructive pulmonary disease (COPD) patients. A significant non-linear association was observed, and BMD ≤ 128.08 mg/cm³ was considered as a critical threshold for lung function assessment. Higher BMD values correlated positively to higher FEV1/FVC%, suggesting that BMD may be a valuable biomarker for evaluating lung function changes in this population. These findings provide new insights into the interplay between bone health and respiratory function in COPD patients.
Publish Date	2025-02-12 02:27
Citation	<p>Gao R, Zeng JK, Yang K, Wang P, Zhou S. Novel association between chronic obstructive pulmonary disease and osteoporosis: A prospective cross-sectional study. <i>World J Orthop</i> 2025; 16(2): 102101</p>
URL	https://www.wjgnet.com/2218-5836/full/v16/i2/102101.htm
DOI	https://dx.doi.org/10.5312/wjo.v16.i2.102101

Full Article (PDF)	WJO-16-102101-with-cover.pdf
STROBE Statement	102101-STROBE-statement.pdf
Manuscript File	102101_Auto_Edited_015411.docx
Answering Reviewers	102101-answering-reviewers.pdf
Audio Core Tip	102101-audio.mp3
Biostatistics Review Certificate	102101-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	102101-conflict-of-interest-statement.pdf
Copyright License Agreement	102101-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	102101-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	102101-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	102101-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	102101-non-native-speakers.pdf
Peer-review Report	102101-peer-reviews.pdf
Scientific Misconduct Check	102101-scientific-misconduct-check.png
Scientific Editor Work List	102101-scientific-editor-work-list.pdf
CrossCheck Report	102101-crosscheck-report.pdf