Publication Name	World Journal of Orthopedics
Manuscript ID	102120
Country	China

Received	2024-10-09 08:21
Peer-Review Started	2024-10-09 08:21
To Make the First Decision
Return for Revision	2024-11-22 13:02
Revised	2024-11-29 04:46
Second Decision	2024-12-20 03:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-20 10:17
Articles in Press	2024-12-20 10:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-12-28 04:19
Typeset the Manuscript	2025-01-03 07:51
Publish the Manuscript Online	2025-01-13 08:26

ISSN	2218-5836 (online)
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Category	Orthopedics
Manuscript Type	Review
Article Title	Role of neurogenic inflammation in intervertebral disc degeneration
Manuscript Source	Invited Manuscript
All Author List	Bao-Gan Peng, Yong-Chao Li and Liang Yang
ORCID	Author(s) ORCID Number Bao-Gan Peng http://orcid.org/0000-0002-7767-9424 Yong-Chao Li http://orcid.org/0000-0002-4460-9702
Funding Agency and Grant Number
Corresponding Author	Bao-Gan Peng, MD, PhD, Chief Physician, Professor, Department of Orthopaedics, The Third Medical Center, General Hospital of the Chinese People’s Liberation Army, No. 69 Yongding Road, Beijing 100039, China. pengbaogan@163.com
Key Words	Intervertebral disc degeneration; Discogenic low back pain; Neurogenic inflammation; Neuropeptides; Neurotrophins; Transient receptor potential channels
Core Tip	The outer layer of the annulus fibrosus (AF) and the vertebral endplate are innervated by nociceptive nerves fibers. Injury to the AF or endplate excites nociceptive stimuli, releasing neuropeptides such as substance P and calcitonin gene related peptide, which results in neurogenic inflammation within the intervertebral disc. Neurogenic inflammation further leads to progressive disc degeneration and chronic discogenic pain through complex interactions between the nervous and immune systems.
Publish Date	2025-01-13 08:26
Citation	<p>Peng BG, Li YC, Yang L. Role of neurogenic inflammation in intervertebral disc degeneration. <i>World J Orthop</i> 2025; 16(1): 102120</p>
URL	https://www.wjgnet.com/2218-5836/full/v16/i1/102120.htm
DOI	https://dx.doi.org/10.5312/wjo.v16.i1.102120

Full Article (PDF)	WJO-16-102120-with-cover.pdf
Manuscript File	102120_Auto_Edited_014302.docx
Answering Reviewers	102120-answering-reviewers.pdf
Audio Core Tip	102120-audio.wav
Conflict-of-Interest Disclosure Form	102120-conflict-of-interest-statement.pdf
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Peer-review Report	102120-peer-reviews.pdf
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Scientific Editor Work List	102120-scientific-editor-work-list.pdf
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CrossCheck Report	102120-crosscheck-report.pdf