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Articles Published Processes
1/21/2025 9:27:09 AM | Browse: 36 | Download: 70
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Received |
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2024-10-11 08:42 |
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Peer-Review Started |
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2024-10-15 01:32 |
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To Make the First Decision |
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Return for Revision |
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2024-12-02 07:05 |
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Revised |
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2024-12-07 10:19 |
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Second Decision |
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2024-12-27 05:55 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-01-08 01:03 |
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Articles in Press |
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2025-01-08 01:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-01-13 00:47 |
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Publish the Manuscript Online |
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2025-01-21 09:27 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
N6-methyladenosine methyltransferase Wilms tumor 1-associated protein impedes diabetic wound healing through epigenetically activating DNA methyltransferase 1
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ren-Jie Xiao, Tian-Jiao Wang, Dan-Yin Wu, Shui-Fa Yang, Hai Gao, Pei-Dong Gan, Yang-Yan Yi and You-Lai Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
You-Lai Zhang, Associate Chief Physician, PhD, Department of Plastic and Cosmetic Surgery, The Second Affiliated Hospital, Jiangxi Medical College of Nanchang University, No. 32 Fuzhou Road, Donghu District, Nanchang 330006, Jiangxi Province, China. youlaizhang@163.com |
| Key Words |
Diabetic wound healing; N6-methyladenosine; Wilms tumor 1-associated protein; DNA methyltransferase 1; Human umbilical vein endothelial cells |
| Core Tip |
Diabetes mellitus is significantly correlated with non-healing wounds, which cause physiological and psychological distress to patients. N6-methyladenosine (m6A)-associated epigenetic regulation plays a crucial role in diabetes mellitus. However, the function of m6A methyltransferase tumor 1-associated protein (WTAP) in diabetic wound healing remains unclear. Our study demonstrated that WTAP was elevated in high glucose-induced human umbilical vein endothelial cells and epigenetically regulates the m6A modification of DNA methyltransferase 1, repressing diabetic wound healing. This study provides novel insights into the mechanisms by which the m6A regulator WTAP inhibits diabetic wound healing. |
| Publish Date |
2025-01-21 09:27 |
| Citation |
<p>Xiao RJ, Wang TJ, Wu DY, Yang SF, Gao H, Gan PD, Yi YY, Zhang YL. N6-methyladenosine methyltransferase Wilms tumor 1-associated protein impedes diabetic wound healing through epigenetically activating DNA methyltransferase 1. <i>World J Diabetes</i> 2025; 16(3): 102126</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i3/102126.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i3.102126 |
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