| ISSN |
1948-5204 (online) |
| Open Access |
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhuo-Cong Bao, Zhao-Dong Liu, Ye Zhang, Hui-Jun Dai, Hui Jia, Fu Ren, Ning Li, Lu Zhao, Yi-Wei Wang, Shang-Yu Lv and Yan Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Central Government Guidance Local Science and Technology Development Fund |
2023JH6/100100021 |
| Liaoning Province Education Department Foundation of China |
JYTMS20231393 |
| Scientific Research Project of Liaoning Province Education Department |
SYYX2019015 |
| Science and Technology Fund of Shenyang Medical College |
20171004 |
| Shenyang Medical College Master’s Science and Technology Innovation Fund |
Y20220509 |
| Liaoning Provincial Department of Education Scientific Research Project |
LJ212410164032 |
|
| Corresponding Author |
Yan Zhang, Associate Professor, PhD, International Education School, International Exchange and Cooperation Office, Shenyang Medical College, No. 146 North Huanghe Street, Shenyang 110034, Liaoning Province, China. zhangyan@symc.edu.cn |
| Key Words |
Hepatocellular carcinoma; Tetrahydrocurcumin; Network pharmacology; Molecular docking; PI3K/AKT signaling pathway |
| Core Tip |
In this comprehensive study, we delved into the anti-cancer potential of tetrahydrocurcumin, meticulously assessing its impact on the proliferation, migration, and invasion of liver cancer cell lines HepG2 and Huh7. Our findings revealed that tetrahydrocurcumin not only effectively inhibited the proliferation and migration of hepatocellular carcinoma cells but also significantly induced apoptosis through the phosphoinositide 3-kinases/AKT signaling pathway, underscoring its therapeutic potential in combating liver cancer. |
| Publish Date |
2025-02-14 10:33 |
| Citation |
<p>Bao ZC, Liu ZD, Zhang Y, Dai HJ, Jia H, Ren F, Li N, Zhao L, Wang YW, Lv SY, Zhang Y. To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway. <i>World J Gastrointest Oncol</i> 2025; 17(3): 102187</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i3/102187.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i3.102187 |
