Publication Name	World Journal of Diabetes
Manuscript ID	102196
Country	China

Received	2024-10-14 05:55
Peer-Review Started	2024-10-19 08:31
To Make the First Decision
Return for Revision	2025-01-12 06:31
Revised	2025-02-09 12:52
Second Decision	2025-03-05 03:00
Accepted by Journal Editor-in-Chief	2025-03-06 10:12
Accepted by Executive Editor-in-Chief	2025-03-18 07:10
Articles in Press	2025-03-18 07:10
Publication Fee Transferred	2025-02-14 02:26
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-11 03:51
Publish the Manuscript Online	2025-04-25 07:54

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pharmacology & Pharmacy
Manuscript Type	Basic Study
Article Title	Shenfushu granules attenuate diabetic kidney disease by inhibiting PIK3R1/protein kinase B/heparanase-mediated endothelial-mesenchymal transition
Manuscript Source	Unsolicited Manuscript
All Author List	Xi-Ding Yang, Si-Jia Ma, Da-Xiong Xiang and Yong-Yu Yang
ORCID	Author(s) ORCID Number Xi-Ding Yang http://orcid.org/0000-0001-5489-6058 Da-Xiong Xiang http://orcid.org/0000-0002-4226-6574 Yong-Yu Yang http://orcid.org/0000-0002-0726-1794
Funding Agency and Grant Number	Funding Agency Grant Number Changsha Science and Technology Major Project No. kh2205035 Hunan Traditional Chinese Medicine Science and Technology Project No. 2021061 Natural Science Foundation of Hunan Province No. 2025JJ80080
Corresponding Author	Yong-Yu Yang, Associate Professor, MD, Department of Pharmacy, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Furong District, Changsha 410011, Hunan Province, China. yongyuyang@csu.edu.cn
Key Words	Diabetic kidney disease; Glomerular filtration barrier; Glycocalyx; Shenfushu granules; PIK3R1; Heparanase-1; Endothelial-mesenchymal transition
Core Tip	Shenfushu granules (SFSGs) can delay the progression of diabetic kidney disease (DKD) by reducing the levels of serum creatinine, urea nitrogen, and urinary microalbumin in DKD mice and reducing damage to glomeruli. SFSGs reduce glomerular endothelial-mesenchymal transition, which is characterized by filtration barrier damage. SFSGs affect the endothelial-mesenchymal transition mediated by the PIK3R1/protein kinase B/heparanase-1 signaling pathway. The main active ingredient of SFSGs strongly binds with PIK3R1.
Publish Date	2025-04-25 07:54
Citation	<p>Yang XD, Ma SJ, Xiang DX, Yang YY. Shenfushu granules attenuate diabetic kidney disease by inhibiting PIK3R1/protein kinase B/heparanase-mediated endothelial-mesenchymal transition. <i>World J Diabetes</i> 2025; 16(5): 102196</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i5/102196.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i5.102196

Full Article (PDF)	WJD-16-102196-with-cover.pdf
The ARRIVE Guidelines	102196-The-ARRIVE-Guidelines.pdf
Manuscript File	102196_Auto_Edited_080220.docx
Answering Reviewers	102196-answering-reviewers.pdf
Audio Core Tip	102196-audio.m4a
Biostatistics Review Certificate	102196-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	102196-conflict-of-interest-statement.pdf
Copyright License Agreement	102196-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	102196-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	102196-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	102196-non-native-speakers.pdf
Supplementary Material	102196-supplementary-material.pdf
Peer-review Report	102196-peer-reviews.pdf
Journal Editor-in-Chief Review Report	102196-journal-editor-in-chief.pdf
Scientific Misconduct Check	102196-scientific-misconduct-check.png
Scientific Editor Work List	102196-scientific-editor-work-list.pdf
CrossCheck Report	102196-crosscheck-report.png
CrossCheck Report	102196-crosscheck-report.pdf