| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Important role of lymphovascular and perineural invasion in prognosis of colorectal cancer patients with N1c disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Gang Sun, Shao-Xuan Chen, Bai-Long Sun, Da-Kui Zhang, Hong-Liang Sun, Huang Chen, Yu-Wan Hu, Tong-Yin Zhang, Zi-Han Han, Wen-Xiao Wu, Zhi-Yong Hou, Li Yao and Jian-Zheng Jie |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National High Level Hospital Clinical Research Funding |
No. 2023-NHLHCRF-BQ-32 |
| National High Level Hospital Clinical Research Funding |
No. 2023-NHLHCRF-YYPPLC-ZR-13 |
| Elite Medical Professionals Project of China-Japan Friendship Hospital |
No. ZRJY2024-GG01 |
|
| Corresponding Author |
Jian-Zheng Jie, Chief Physician, MD, Department of General Surgery, China-Japan Friendship Hospital, No.2 Yinghuayuan East Street, Chaoyang District, Beijing 100029, China. jianzhengjie@sohu.com |
| Key Words |
Colorectal cancer; N1c; Lymphovascular invasion; Perineural invasion; Prognosis |
| Core Tip |
This study evaluated lymphovascular invasion (LVI) and perineural invasion (PNI) as prognostic indicators in N1c colorectal cancer. Among 107 N1c patients, 21.5% were LVI-positive and 44.9% were PNI-positive. Five-year disease-free survival (DFS) rates were higher for LVI-negative (74.0%) and PNI-negative (82.5%) patients than LVI-positive (35.6%) and PNI-positive (45.1%) patients. On multivariate analysis, both LVI and PNI were independent prognostic factors. Receiver operating characteristic curve analysis showed good predictive ability for DFS, overall survival and cancer-specific survival. Patients with LVI or PNI should be closely monitored during treatment. |
| Publish Date |
2024-12-30 09:50 |
| Citation |
<p>Sun ZG, Chen SX, Sun BL, Zhang DK, Sun HL, Chen H, Hu YW, Zhang TY, Han ZH, Wu WX, Hou ZY, Yao L, Jie JZ. Important role of lymphovascular and perineural invasion in prognosis of colorectal cancer patients with N1c disease. <i>World J Gastroenterol</i> 2025; 31(5): 102210</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i5/102210.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i5.102210 |
