Publication Name	World Journal of Gastroenterology
Manuscript ID	102256
Country	China

Received	2024-10-13 09:45
Peer-Review Started	2024-10-13 09:45
To Make the First Decision
Return for Revision	2024-11-21 16:22
Revised	2024-12-06 17:23
Second Decision	2025-01-02 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-02 06:58
Articles in Press	2025-01-02 06:58
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-01-13 00:58
Typeset the Manuscript	2025-01-24 09:50
Publish the Manuscript Online	2025-02-18 09:00

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation
Manuscript Source	Unsolicited Manuscript
All Author List	Xue-Jiao Liu, Yeliya Yeertai, Yue-Bo Jia, Chen-Heng Wu, Xiang-Xiang Wang, Ke-Ming Yang, Xuan Yao and Jiang-Hong Ling
ORCID	Author(s) ORCID Number Jiang-Hong Ling http://orcid.org/0000-0001-7550-9694
Funding Agency and Grant Number	Funding Agency Grant Number Joint Funds of the National Natural Science Foundation of China 82174309 Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Simei Fund Special Project for Scientific Research SGKJ-202304
Corresponding Author	Jiang-Hong Ling, PhD, Professor, Department of Gastroenterology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No. 185 Pu'an Road, Huangpu District, Shanghai 200021, China. ljh18817424778@163.com
Key Words	Traditional Chinese medicine; Functional constipation; NLRP6; Autophagy; Mucosal microbiota; Mucin; The goblet cells
Core Tip	Runchangningshen paste (RCNSP) is used to treat functional constipation (FC). Based on the UPLC-MS/MS, animal experiments, and the gut microbiota sequencing, we found that RCNSP could activate the inflammasome-mediated autophagy pathway to promote Mucin-2 (MUC2) secretion and modulate the mucosal microbiota. In addition, mucosal microbiota might also promote MUC2 secretion by activating the NLRP6-mediated autophagy pathway. These findings offer valuable information on the therapeutic efficacy of RCNSP and enhance the theoretical basis of traditional Chinese medicine regarding the nourishment of yin and blood for treating FC.
Publish Date	2025-02-18 09:00
Citation	<p>Liu XJ, Yeertai Y, Jia YB, Wu CH, Wang XX, Yang KM, Yao X, Ling JH. Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation. <i>World J Gastroenterol</i> 2025; 31(9): 102256</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i9/102256.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i9.102256

Full Article (PDF)	WJG-31-102256-with-cover.pdf
The ARRIVE Guidelines	102256-The-ARRIVE-Guidelines.pdf
Manuscript File	102256_Auto_Edited_082743.docx
Answering Reviewers	102256-answering-reviewers.pdf
Audio Core Tip	102256-audio.mp3
Biostatistics Review Certificate	102256-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	102256-conflict-of-interest-statement.pdf
Copyright License Agreement	102256-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	102256-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	102256-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	102256-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	102256-non-native-speakers.pdf
Supplementary Material	102256-supplementary-material.pdf
Peer-review Report	102256-peer-reviews.pdf
Scientific Misconduct Check	102256-scientific-misconduct-check.png
Scientific Editor Work List	102256-scientific-editor-work-list.pdf
CrossCheck Report	102256-crosscheck-report.pdf