Publication Name	World Journal of Hepatology
Manuscript ID	102273
Country	China

Received	2024-10-14 11:57
Peer-Review Started	2024-10-23 15:39
To Make the First Decision
Return for Revision	2024-11-11 08:51
Revised	2024-11-12 12:26
Second Decision	2024-11-27 02:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-27 08:03
Articles in Press	2024-11-27 08:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-20 06:46
Publish the Manuscript Online	2025-01-06 08:47

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Advances and challenges in molecular understanding, early detection, and targeted treatment of liver cancer
Manuscript Source	Invited Manuscript
All Author List	Ji Shi, Xu Zhu and Jun-Bo Yang
ORCID	Author(s) ORCID Number Ji Shi http://orcid.org/0000-0002-7983-4686 Jun-Bo Yang http://orcid.org/0000-0003-2187-5749
Funding Agency and Grant Number
Corresponding Author	Jun-Bo Yang, Associate Professor, PhD, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, No. 97 Buxin Road, Dapeng New District, Shenzhen 518000, Guangdong Province, China. 1806389316@pku.edu.cn
Key Words	Liver cancer; Molecular mechanisms; Next-generation sequencing; Early detection; Wnt/β-catenin signaling
Core Tip	This review delves into the complexities of hepatocellular carcinoma (HCC); a highly aggressive form of liver cancer with a low 5-year survival rate and limited treatment options. It examines various factors contributing to HCC, highlights the need for improved early detection using biomarkers and advanced techniques like next-generation sequencing, and emphasizes the importance of understanding the molecular mechanisms involved, particularly the Wnt/β-catenin signaling pathway, to provide evidence for the development of more effective and personalized therapies.
Publish Date	2025-01-06 08:47
Citation	<p>Shi J, Zhu X, Yang JB. Advances and challenges in molecular understanding, early detection, and targeted treatment of liver cancer. <i>World J Hepatol</i> 2025; 17(1): 102273</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i1/102273.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i1.102273

Full Article (PDF)	WJH-17-102273-with-cover.pdf
Manuscript File	102273_Auto_Edited_015121.docx
Answering Reviewers	102273-answering-reviewers.pdf
Audio Core Tip	102273-audio.mp3
Conflict-of-Interest Disclosure Form	102273-conflict-of-interest-statement.pdf
Copyright License Agreement	102273-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	102273-non-native-speakers.pdf
Peer-review Report	102273-peer-reviews.pdf
Scientific Misconduct Check	102273-scientific-misconduct-check.png
Scientific Editor Work List	102273-scientific-editor-work-list.pdf
CrossCheck Report	102273-crosscheck-report.png
CrossCheck Report	102273-crosscheck-report.pdf