| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Basic Study |
| Article Title |
Role of duodenal mucosal resurfacing in controlling diabetes in rats
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Juan Nie, Zhe Cheng, Yi-Xian He, Qian-Hua Yan, Yao-Huan Sun, Xin-Yi Yang, Jie Tian, Peng-Fei Zhu, Jiang-Yi Yu, Hui-Ping Zhou and Xi-Qiao Zhou |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82474318 |
| Jiangsu Administration of Traditional Chinese Medicine |
No. zt202105 |
| Subject of Jiangsu Province Hospital of Chinese Medicine |
No. Y2021rc22 |
| Research Career Scientist Award (to Zhou HP) from the Department of Veterans Affairs (United States) |
No. 2IK6BX004477-06 |
|
| Corresponding Author |
Xi-Qiao Zhou, PhD, Professor, Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, No. 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. zhouxiqiao@njucm.edu.cn |
| Key Words |
Type 2 diabetes; Duodenal mucosal resurfacing; Gut microbiota; Insulin resistance; Blautia; Gastric inhibitory peptide; Glucagon-like peptide 1 |
| Core Tip |
Duodenum is a particular metabolic signaling center, and the thickened mucous membranes cause duodenal dysfunction and promote insulin resistance. This study explored the mechanisms by which duodenal mucosal resurfacing (DMR) affects type 2 diabetes (T2D) using a rat model. It highlights the potential role of the Blautia genus in the pathogenesis of T2D and the therapeutic effect of DMR. The results provide a theoretical basis for performing DMR in humans with T2D and identify several areas requiring further research. |
| Publish Date |
2025-01-21 09:27 |
| Citation |
<p>Nie LJ, Cheng Z, He YX, Yan QH, Sun YH, Yang XY, Tian J, Zhu PF, Yu JY, Zhou HP, Zhou XQ. Role of duodenal mucosal resurfacing in controlling diabetes in rats. <i>World J Diabetes</i> 2025; 16(3): 102277</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i3/102277.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i3.102277 |
