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Articles Published Processes
4/16/2025 5:36:37 AM | Browse: 19 | Download: 41
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Received |
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2024-10-14 01:03 |
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Peer-Review Started |
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2024-10-23 15:43 |
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To Make the First Decision |
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Return for Revision |
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2024-12-17 05:29 |
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Revised |
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2024-12-31 19:58 |
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Second Decision |
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2025-01-10 02:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-01-11 09:35 |
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Articles in Press |
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2025-01-11 09:35 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-02-27 01:40 |
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Publish the Manuscript Online |
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2025-04-16 05:36 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Review |
| Article Title |
Dynamics of inflammatory signals within the tumor microenvironment
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hala Issa, Lokjan Singh, Kok-Song Lai, Tina Parusheva-Borsitzky and Shamshul Ansari |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Shamshul Ansari, Assistant Professor, PhD, Division of Health Sciences, Higher Colleges of Technology, Baniyas, Abu Dhabi 25026, United Arab Emirates. shamshulansari483@yahoo.com |
| Key Words |
Inflammatory signals; Tumor microenvironment; Cytokines; Interleukins; Transforming growth factor |
| Core Tip |
Tumor microenvironment consisting of the cancer related fibroblasts can inhibit the tumor cell killing activity of cytotoxic T-cells. This activity is promoted by secretion of a variety of immunosuppressive cytokines, such as interleukins (ILs) and transforming growth factor beta (TGF-β). IL-1 has been found to be associated with tumor growth and its dissemination in the body. Similarly, other cytokines and inflammatory proteins such as IL-6, IL-33, TGF-β, nuclear factor kappa-B, IL-6, signal transducer and activator of transcription 3 pathway, interferons and toll-like receptors have been linked to tumor invasion and immunosuppression, creating conditions that facilitate tumor growth and metastasis. |
| Publish Date |
2025-04-16 05:36 |
| Citation |
<p>Issa H, Singh L, Lai KS, Parusheva-Borsitzky T, Ansari S. Dynamics of inflammatory signals within the tumor microenvironment. <i>World J Exp Med</i> 2025; 15(2): 102285</p> |
| URL |
https://www.wjgnet.com/2220-315x/full/v15/i2/102285.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i2.102285 |
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