| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Overcoming antibiotic-resistant Helicobacter pylori infection: Current challenges and emerging approaches
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Gabriel Reis Rocha, Fabian Fellipe Bueno Lemos, Luis Guilherme de Oliveira Silva, Marcel Silva Luz, Gabriel Lima Correa Santos, Samuel Luca Rocha Pinheiro, Mariana Santos Calmon and Fabrício Freire de Melo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Industrial Technological Initiation Scholarship of National Council for Scientific and Technological Development, CNPq, Brazil |
0932204294929829, 7414780530977345 |
| Scientific Initiation Scholarship Programme (PIBIC) of National Council for Scientific and Technological Development, CNPq, Brazil |
5763023359532159, 6472982965854452 |
| Scientific Initiation Scholarship Programme (PIBIC) of National Council for Scientific and Technological Development, CNPq, Brazil |
7340128440641417 |
| Scientific Initiation Scholarship Programme (PIBIC) of Bahia State Research Support Foundation, FAPESB, Brazil |
19.573.301.5418 |
| PERMANECER Programme of Pro-Rectory of Student Assistance at Federal University of Bahia |
R8EZ-4V4W-6LQX-5LC8 |
| CNPq Research Productivity Fellow |
4357511882624145 |
|
| Corresponding Author |
Fabrício Freire de Melo, PhD, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Quadra 17, Lote 58, Vitória da Conquista 45029-094, Bahia, Brazil. freiremeloufba@gmail.com |
| Key Words |
Helicobacter pylori; Antibiotic resistance; Multidrug resistance; Heteroresistance; Empirical treatment; Antimicrobial susceptibility testing |
| Core Tip |
The rise of antibiotic resistance in Helicobacter pylori (H. pylori) has become a global concern, reducing the efficacy of conventional therapies. Resistant H. pylori strains, often inadequately mapped by regional surveillance, frequently demand multiple eradication attempts, imposing considerable financial burdens, adverse effects and contributing to secondary resistance development. This study aims to provide a comprehensive review of the current landscape of mechanisms and prevalence of H. pylori resistance and summarize promising therapeutic alternatives under evaluation. These strategies might improve treatment efficacy, enhancing patient outcomes in this challenging scenario. |
| Publish Date |
2025-02-26 04:21 |
| Citation |
<p>Rocha GR, Lemos FFB, Silva LGO, Luz MS, Correa Santos GL, Rocha Pinheiro SL, Calmon MS, de Melo FF. Overcoming antibiotic-resistant Helicobacter pylori infection: Current challenges and emerging approaches. <i>World J Gastroenterol</i> 2025; 31(10): 102289</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i10/102289.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i10.102289 |
