Publication Name	World Journal of Cardiology
Manuscript ID	102308
Country	China

Received	2024-10-14 11:58
Peer-Review Started	2024-10-16 00:52
To Make the First Decision
Return for Revision	2024-11-27 01:07
Revised	2024-12-10 15:04
Second Decision	2025-02-08 02:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-08 09:48
Articles in Press	2025-02-08 09:48
Publication Fee Transferred	2024-12-11 04:03
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-02-17 08:04
Publish the Manuscript Online	2025-02-25 06:14

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Emerging roles of the acid sphingomyelinase/ceramide pathway in metabolic and cardiovascular diseases: Mechanistic insights and therapeutic implications
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Ni Wang, Ye Wang, Si-Yao Zhang and Lan Bai
ORCID	Author(s) ORCID Number Hong-Ni Wang http://orcid.org/0009-0003-8402-3989 Lan Bai http://orcid.org/0000-0002-8859-1540
Funding Agency and Grant Number	Funding Agency Grant Number Ganzhou City’s “Light of the Soviet Area” Talent Project GZSQZG202301009
Corresponding Author	Lan Bai, PhD, Professor, State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Huangjin Campus, University Town, Rongjiang New District, Ganzhou 341000, Jiangxi Province, China. bailan@gmu.edu.cn
Key Words	Acid sphingomyelinase; Ceramide; Metabolic and cardiovascular diseases; Glycolipid metabolism; Inflammation; Mitochondrial homeostasis
Core Tip	Metabolic diseases represent a major global public health challenge, and the mechanisms of the acid sphingomyelinase/ceramide (ASMase/Cer) pathway in these diseases remain under-explored. This review synthesizes recent studies on the biological functions, regulatory mechanisms, and targeted therapies associated with the ASMase/Cer pathway in metabolic conditions including obesity, diabetes mellitus, non-alcoholic fatty liver disease, and cardiovascular disease. The effects of the ASMase/Cer pathway on glucose-lipid metabolism, insulin resistance, inflammation and mitochondrial homeostasis are elucidated. The insights provided in this review could aid in the development of therapeutic interventions for metabolic diseases and their severe complications.
Publish Date	2025-02-25 06:14
Citation	<p>Wang HN, Wang Y, Zhang SY, Bai L. Emerging roles of the acid sphingomyelinase/ceramide pathway in metabolic and cardiovascular diseases: Mechanistic insights and therapeutic implications. <i>World J Cardiol</i> 2025; 17(2): 102308</p>
URL	https://www.wjgnet.com/1949-8462/full/v17/i2/102308.htm
DOI	https://dx.doi.org/10.4330/wjc.v17.i2.102308

Full Article (PDF)	WJC-17-102308-with-cover.pdf
Manuscript File	102308_Auto_Edited_032215.docx
Answering Reviewers	102308-answering-reviewers.pdf
Audio Core Tip	102308-audio.m4a
Conflict-of-Interest Disclosure Form	102308-conflict-of-interest-statement.pdf
Copyright License Agreement	102308-copyright-assignment.pdf
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Non-Native Speakers of English Editing Certificate	102308-non-native-speakers.pdf
Peer-review Report	102308-peer-reviews.pdf
Scientific Misconduct Check	102308-scientific-misconduct-check.png
Scientific Editor Work List	102308-scientific-editor-work-list.pdf
CrossCheck Report	102308-crosscheck-report.pdf