| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Assessment of the biosafety profile of Galium verum in vitro on myoblasts and in ovo on chorioallantoic membrane
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Diana Maria Morariu-Briciu, Sorin Lucian Bolintineanu, Andreea Rata, Alexandra Denisa Semenescu, Alina Anton, Robert Jijie, Andreea Kis, Ingrid Hrubaru and Alina Heghes |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Alina Anton, Assistant Professor, Department of Toxicology, Drug Industry, Management and Legislation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu square nr 2, Timisoara 300041, Romania. dolghi.alina@umft.ro |
| Key Words |
Galium verum L; Ethanolic extract; Cardiomyocytes; Ischemic heard; Cellular viability stimulation; In vitro; In ovo |
| Core Tip |
Ischemic heart disease is a condition that attacks a growing number of patients every day, despite advances in the medical field. This phenomenon implies the need to identify new therapeutic approaches. Galium verum (G. verum) is a plant with cardio-protective effects, able to maintain cardiac contractility. However, until now, no in vitro or in ovo studies of G. verum extract on cardiomyoblasts and vascular plexus have been performed. Thus, in the current study, this aspect was followed, observing a stimulating effect of the plant on the H9C2(2-1) cell line, without signs of apoptosis, without pronounced irritating effects in ovo, and with a protective effect on the chorioallantoic membrane. |
| Publish Date |
2025-02-25 06:14 |
| Citation |
Morariu-Briciu DM, Bolintineanu SL, Rata A, Semenescu AD, Anton A, Jijie R, Kis A, Hrubaru I, Heghes A. Assessment of the biosafety profile of Galium verum in vitro on myoblasts and in ovo on chorioallantoic membrane. World J Cardiol 2025; 17(2): 102310 |
| URL |
https://www.wjgnet.com/1949-8462/full/v17/i2/102310.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v17.i2.102310 |
