Publication Name	World Journal of Gastroenterology
Manuscript ID	10232
Country	Germany

Received	2014-03-20 22:21
Peer-Review Started	2014-03-21 13:34
To Make the First Decision	2014-04-15 19:39
Return for Revision	2014-04-23 21:06
Revised	2014-05-10 00:33
Second Decision	2014-06-23 10:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-23 10:14
Articles in Press	2014-06-23 10:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-10-21 11:27
Publish the Manuscript Online	2014-10-29 19:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Modulating effects of acyl-CoA synthetase 5-derived mitochondrial Wnt2B palmitoylation on intestinal Wnt activity
Manuscript Source	Unsolicited Manuscript
All Author List	Christina Klaus, Ursula Schneider, Christian Hedberg, Anke K Schütz, Jürgen Bernhagen, Herbert Waldmann, Nikolaus Gassler and Elke Kaemmerer
Funding Agency and Grant Number	Funding Agency Grant Number Deutsche Forschungsgemeinschaft DFG GA 785/5-1 Deutsche Krebshilfe GA 109313
Corresponding Author	Nikolaus Gassler, Professor, Institute of Pathology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. ngassler@ukaachen.de
Key Words	Acyl-CoA synthetases; Wnt signaling; Palmitoylation; Intestinal barrier; Carcinogenesis
Core Tip	Acyl-CoA synthetase 5 (ACSL5) plays a key role in fatty acid metabolism. Besides its proapoptotic effects along the crypt-villus-axis ACSL5 also functions as an antiproliferative modifier of Wnt signaling activity. In the presence of ACSL5, Wnt2B was S-palmitoylated and thereby enriched in mitochondria, which was paralleled by a significant decrease in Wnt activity. The molecular pathway is probably of relevance for the homeostasis of the intestinal barrier.
Publish Date	2014-10-29 19:34
Citation	Klaus C, Schneider U, Hedberg C, Schütz AK, Bernhagen J, Waldmann H, Gassler N, Kaemmerer E. Modulating effects of acyl-CoA synthetase 5-derived mitochondrial Wnt2B palmitoylation on intestinal Wnt activity. World J Gastroenterol 2014; 20(40): 14855-14864
URL	http://www.wjgnet.com/1007-9327/full/v20/i40/14855.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i40.14855

Full Article (PDF)	WJG-20-14855.pdf
Full Article (Word)	WJG-20-14855.doc
Manuscript File	10232-Review.doc
Answering Reviewers	10232-Answering reviewers.pdf
Copyright License Agreement	10232-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	10232-Language certificate.pdf
Peer-review Report	10232-Peer review.pdf
Scientific Misconduct Check	10232-CorssCheck.jpg
Scientific Editor Work List	10232-Scientific editor work list.pdf