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10/29/2014 7:34:00 PM | Browse: 608 | Download: 698
Publication Name World Journal of Gastroenterology
Manuscript ID 10232
Country/Territory Germany
Received
2014-03-20 22:21
Peer-Review Started
2014-03-21 13:34
To Make the First Decision
2014-04-15 19:39
Return for Revision
2014-04-23 21:06
Revised
2014-05-10 00:33
Second Decision
2014-06-23 10:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-06-23 10:14
Articles in Press
2014-06-23 10:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-10-21 11:27
Publish the Manuscript Online
2014-10-29 19:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title Modulating effects of acyl-CoA synthetase 5-derived mitochondrial Wnt2B palmitoylation on intestinal Wnt activity
Manuscript Source Unsolicited Manuscript
All Author List Christina Klaus, Ursula Schneider, Christian Hedberg, Anke K Schütz, Jürgen Bernhagen, Herbert Waldmann, Nikolaus Gassler and Elke Kaemmerer
Funding Agency and Grant Number
Funding Agency Grant Number
Deutsche Forschungsgemeinschaft DFG GA 785/5-1
Deutsche Krebshilfe GA 109313
Corresponding author Nikolaus Gassler, Professor, Institute of Pathology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. ngassler@ukaachen.de
Key Words Acyl-CoA synthetases; Wnt signaling; Palmitoylation; Intestinal barrier; Carcinogenesis
Core Tip Acyl-CoA synthetase 5 (ACSL5) plays a key role in fatty acid metabolism. Besides its proapoptotic effects along the crypt-villus-axis ACSL5 also functions as an antiproliferative modifier of Wnt signaling activity. In the presence of ACSL5, Wnt2B was S-palmitoylated and thereby enriched in mitochondria, which was paralleled by a significant decrease in Wnt activity. The molecular pathway is probably of relevance for the homeostasis of the intestinal barrier.
Publish Date 2014-10-29 19:34
Citation Klaus C, Schneider U, Hedberg C, Schütz AK, Bernhagen J, Waldmann H, Gassler N, Kaemmerer E. Modulating effects of acyl-CoA synthetase 5-derived mitochondrial Wnt2B palmitoylation on intestinal Wnt activity. World J Gastroenterol 2014; 20(40): 14855-14864
Url http://www.wjgnet.com/1007-9327/full/v20/i40/14855.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i40.14855
Full Article (PDF) WJG-20-14855.pdf
Full Article (Word) WJG-20-14855.doc
Manuscript File 10232-Review.doc
Answering Reviewers 10232-Answering reviewers.pdf
Copyright License Agreement 10232-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 10232-Language certificate.pdf
Peer-review Report 10232-Peer review.pdf
Scientific Misconduct Check 10232-CorssCheck.jpg
Scientific Editor Work List 10232-Scientific editor work list.pdf