Publication Name	World Journal of Hepatology
Manuscript ID	102375
Country	Belgium

Received	2024-10-15 15:10
Peer-Review Started	2024-10-15 15:10
To Make the First Decision
Return for Revision	2024-11-25 08:11
Revised	2024-12-06 10:57
Second Decision	2025-01-06 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-07 10:30
Articles in Press	2025-01-07 10:30
Publication Fee Transferred	2024-12-13 08:26
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-20 07:41
Publish the Manuscript Online	2025-02-20 08:39

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Early plasmapheresis in type 2 benign recurrent intrahepatic cholestasis: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Lander Heyerick, Annemieke Dhondt, Hans Van Vlierberghe, Xavier Verhelst, Sarah Raevens and Anja Geerts
ORCID	Author(s) ORCID Number Lander Heyerick http://orcid.org/0000-0002-5314-0707 Annemieke Dhondt http://orcid.org/0000-0002-7954-5075 Hans Van Vlierberghe http://orcid.org/0000-0003-0647-9238 Xavier Verhelst http://orcid.org/0000-0002-2798-5415 Sarah Raevens http://orcid.org/0000-0003-2810-7507 Anja Geerts http://orcid.org/0000-0002-2218-9081
Funding Agency and Grant Number
Corresponding Author	Lander Heyerick, MD, Department of Gastroenterology and Hepatology, Ghent University Hospital, Corneel Heymanslaan 10, Ghent 9000, Belgium. lander.heyerick@uzgent.be
Key Words	Cholestasis; Benign recurrent intrahepatic 2; Plasmapheresis; Pruritus; Cholestasis; Bile salt export pump; Case report
Core Tip	This case report highlights the successful use of early plasmapheresis in managing a patient with pruritus due to a cholestatic episode of benign recurrent intrahepatic cholestasis type 2, triggered by severe acute respiratory syndrome coronavirus 2 infection. Plasmapheresis provided rapid relief from severe pruritus when first-line therapies failed and, when reinitiated early during a consequent flare, significantly accelerated recovery from cholestasis. While the procedure’s invasiveness and associated costs underscore the importance of careful patient selection, prompt initiation should be considered in therapy-refractory cases to optimize outcomes.
Publish Date	2025-02-20 08:39
Citation	<p>Heyerick L, Dhondt A, Van Vlierberghe H, Verhelst X, Raevens S, Geerts A. Early plasmapheresis in type 2 benign recurrent intrahepatic cholestasis: A case report and review of literature. <i>World J Hepatol</i> 2025; 17(2): 102375</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i2/102375.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i2.102375

Full Article (PDF)	WJH-17-102375-with-cover.pdf
CARE Checklist–2016	102375-CARE-Checklist-2016.pdf
Manuscript File	102375_Auto_Edited_005253.docx
Answering Reviewers	102375-answering-reviewers.pdf
Audio Core Tip	102375-audio.mp3
Conflict-of-Interest Disclosure Form	102375-conflict-of-interest-statement.pdf
Copyright License Agreement	102375-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s)	102375-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate	102375-non-native-speakers.pdf
Peer-review Report	102375-peer-reviews.pdf
Scientific Misconduct Check	102375-scientific-misconduct-check.png
Scientific Editor Work List	102375-scientific-editor-work-list.pdf
CrossCheck Report	102375-crosscheck-report.pdf