| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Long noncoding RNA SNHG5 promotes 5-fluorouracil resistance in colorectal cancer by regulating miR-26b/p-glycoprotein axis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bin Wang, Qian Zhou, Cui-E Cheng, Yi-Jie Gu, Ting-Wang Jiang, Jia-Ming Qiu, Gui-Ning Wei, Ya-Dong Feng, Li-Hua Ren and Rui-Hua Shi |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82404088 |
| China Postdoctoral Science Foundation |
No. 2023M730587 |
| Changshu Talent Scientific Project |
No. KCH202304 |
|
| Corresponding Author |
Rui-Hua Shi, MD, Professor, School of Medicine, Southeast University, No. 87 Dingjiaqiao Road, Gulou District, Nanjing 210009, Jiangsu Province, China. ruihuashi@126.com |
| Key Words |
SNHG5; 5-fluorouracil resistance; Colorectal cancer; MiR-26b; P-glycoprotein; Long noncoding RNA; Therapeutic target |
| Core Tip |
This study confirmed that the expression of the long noncoding RNA SNHG5 was upregulated in 5-fluorouracil (5-Fu)-resistant colorectal cancer (CRC) tissues and 5-Fu-resistant CRC cells. Functional experiments confirmed that SNHG5 overexpression reduced 5-Fu sensitivity in CRC in vitro and in vivo. Mechanistically, SNHG5 acted as a molecular sponge for miR-26b. In addition, SNHG5 conferred 5-Fu resistance in CRC by regulating the miR-26b/p-glycoprotein axis. Our results elucidate potential mechanisms of noncoding RNAs in CRC chemoresistance and provide new strategies for CRC chemotherapy. |
| Publish Date |
2025-05-15 10:28 |
| Citation |
<p>Wang B, Zhou Q, Cheng CE, Gu YJ, Jiang TW, Qiu JM, Wei GN, Feng YD, Ren LH, Shi RH. Long noncoding RNA SNHG5 promotes 5-fluorouracil resistance in colorectal cancer by regulating miR-26b/p-glycoprotein axis. <i>World J Gastrointest Oncol</i> 2025; 17(5): 102417</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i5/102417.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i5.102417 |
