Publication Name	World Journal of Stem Cells
Manuscript ID	102421
Country	China

Received	2024-10-18 04:03
Peer-Review Started	2024-10-18 04:04
To Make the First Decision
Return for Revision	2025-01-10 01:33
Revised	2025-01-23 12:12
Second Decision	2025-02-28 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-03 06:32
Articles in Press	2025-03-03 06:32
Publication Fee Transferred	2025-01-26 08:38
Edit the Manuscript by Language Editor	2025-03-10 01:09
Typeset the Manuscript	2025-03-28 07:54
Publish the Manuscript Online	2025-04-23 03:33

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell & Tissue Engineering
Manuscript Type	Systematic Reviews
Article Title	Effectiveness of mesenchymal stem cell-derived extracellular vesicles therapy for Parkinson’s disease: A systematic review of preclinical studies
Manuscript Source	Unsolicited Manuscript
All Author List	Xue-Song Wang, Yue Wang, Yan Xu, Shan-Rong Zhang, Yang Zhang, Lu-Lu Peng, Nan Wu and Jun-Song Ye
ORCID	Author(s) ORCID Number Xue-Song Wang http://orcid.org/0009-0001-1816-4981 Jun-Song Ye http://orcid.org/0000-0003-4336-1933
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 32060232 Natural Science Foundation of Jiangxi Province 20212BAB206075
Corresponding Author	Jun-Song Ye, Chief Physician, MD, PhD, Professor, Subcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, No. 23 Qingnian Road, Ganzhou 341000, Jiangxi Province, China. yjs1211@163.com
Key Words	Mesenchymal stem cell; Extracellular vesicles; Exosomes; Stem cell therapy; Parkinson’s disease; Systematic review
Core Tip	Mesenchymal stem cell extracellular vesicles (MSC-EVs) have become a popular direction for tissue engineering research in recent years and have been shown to have many advantages, especially in neurological diseases with strong potential. Unfortunately, the treatment of Parkinson’s disease (PD) with MSC-EVs is still in the clinical void stage due to insufficient guideline protocols to rely on. Our study is the first to validate the efficacy and durability of MSC-EVs in the treatment of PD and to draw a number of valuable guiding conclusions. The results of our analyses are of great reference value for future clinical translation of stem cell exosomes for PD.
Publish Date	2025-04-23 03:33
Citation	<p>Wang XS, Wang Y, Xu Y, Zhang SR, Zhang Y, Peng LL, Wu N, Ye JS. Effectiveness of mesenchymal stem cell-derived extracellular vesicles therapy for Parkinson’s disease: A systematic review of preclinical studies. <i>World J Stem Cells</i> 2025; 17(4): 102421</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i4/102421.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i4.102421

Full Article (PDF)	WJSC-17-102421-with-cover.pdf
PRISMA 2009 Checklist	102421-PRISMA-2009-Checklist.pdf
Manuscript File	102421_Auto_Edited_012218.docx
Answering Reviewers	102421-answering-reviewers.pdf
Audio Core Tip	102421-audio.mp3
Biostatistics Review Certificate	102421-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	102421-conflict-of-interest-statement.pdf
Copyright License Agreement	102421-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	102421-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	102421-non-native-speakers.pdf
Supplementary Material	102421-supplementary-material.pdf
Peer-review Report	102421-peer-reviews.pdf
Scientific Misconduct Check	102421-scientific-misconduct-check.png
Scientific Editor Work List	102421-scientific-editor-work-list.pdf
CrossCheck Report	102421-crosscheck-report.pdf