Publication Name	World Journal of Gastroenterology
Manuscript ID	102423
Country	China

Received	2024-10-18 05:56
Peer-Review Started	2024-10-18 05:57
To Make the First Decision
Return for Revision	2025-01-04 01:00
Revised	2025-01-14 02:27
Second Decision	2025-03-06 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-06 03:29
Articles in Press	2025-03-06 03:29
Publication Fee Transferred	2025-01-17 01:27
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-14 02:09
Publish the Manuscript Online	2025-03-26 08:40

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Pharmacology & Pharmacy
Manuscript Type	Opinion Review
Article Title	To activate a G protein-coupled receptor permanently with cell surface photodynamic action in the gastrointestinal tract
Manuscript Source	Unsolicited Manuscript
All Author List	Zong-Jie Cui
ORCID	Author(s) ORCID Number Zong-Jie Cui http://orcid.org/0000-0003-4252-4876
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 32271278 National Natural Science Foundation of China No. 31971170
Corresponding Author	Zong-Jie Cui, PhD, Professor, Department of Biology, College of Life Sciences, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China. zjcui@bnu.edu.cn
Key Words	Cholecystokinin 1 receptor; Singlet oxygen; G protein coupled receptor activated by singlet oxygen; Genetically encoded protein photosensitizers; Calcium oscillations; Pancreatic acinar cells
Core Tip	G protein coupled receptors (GPCR) are a large group of functional proteins, whose ligands account for a large proportion of clinical drugs. Important as GPCR may be, their ligand-independent pharmacology is poorly investigated. This minireview shows that the A class GPCR cholecystokinin 1 receptor, predominantly expressed in pancreatic acini, could be activated permanently by singlet oxygen in photodynamic action. Three lines of evidence regarding mechanisms of photodynamic activation is presented. Clues suggest that permanent photodynamic activation of other GPCR and other functional proteins are possible, permanent photodynamic activation may be a general principle, both in gastrointestinal tract and elsewhere.
Publish Date	2025-03-26 08:40
Citation	<p>Cui ZJ. To activate a G protein-coupled receptor permanently with cell surface photodynamic action in the gastrointestinal tract. <i>World J Gastroenterol</i> 2025; 31(12): 102423</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i12/102423.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i12.102423

Full Article (PDF)	WJG-31-102423-with-cover.pdf
Manuscript File	102423_Auto_Edited_005557.docx
Answering Reviewers	102423-answering-reviewers.pdf
Audio Core Tip	102423-audio.m4a
Conflict-of-Interest Disclosure Form	102423-conflict-of-interest-statement.pdf
Copyright License Agreement	102423-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	102423-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	102423-non-native-speakers.pdf
Supplementary Material	102423-supplementary-material.pdf
Peer-review Report	102423-peer-reviews.pdf
Scientific Misconduct Check	102423-scientific-misconduct-check.png
Scientific Editor Work List	102423-scientific-editor-work-list.pdf
CrossCheck Report	102423-crosscheck-report.png
CrossCheck Report	102423-crosscheck-report.pdf