Publication Name	World Journal of Stem Cells
Manuscript ID	102482
Country	Greece

Received	2024-10-21 06:38
Peer-Review Started	2024-10-21 06:40
To Make the First Decision
Return for Revision	2025-01-09 02:45
Revised	2025-02-06 15:37
Second Decision	2025-03-05 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-05 06:23
Articles in Press	2025-03-05 06:23
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-03-12 04:06
Typeset the Manuscript	2025-04-10 03:32
Publish the Manuscript Online	2025-04-23 03:33

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Letter to the Editor
Article Title	MicroRNAs derived from the hypoxic endometrial epithelial cells effectively regulate the regenerative properties of mesenchymal stromal cells
Manuscript Source	Invited Manuscript
All Author List	Panagiotis Mallis
ORCID	Author(s) ORCID Number Panagiotis Mallis http://orcid.org/0000-0001-9429-190X
Funding Agency and Grant Number
Corresponding Author	Panagiotis Mallis, PhD, Postdoctoral Fellow, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 4 Soranou Ephessiou Street, Athens 11527, Attikí, Greece. pmallis@bioacademy.gr
Key Words	MicroRNAs; Mesenchymal stromal cells; Endometrial tissue; Wound healing; Tissue regeneration; MiR-214-5p; MiR-21-5p
Core Tip	Endometrial tissue damage is the primary reason for unsuccessful embryo implantation. Hypoxic damaged endometrial epithelial cells can secrete miRNAs through exosomes, which efficiently can regulate the homeostasis of the endometrial microenvironment. Specifically, miR-21-5p and miR-214-5p can regulate the migratory, wound healing and differentiation of umbilical cord derived mesenchymal stromal cells, therefore, the latter favors the endometrial tissue regeneration. Understanding the primary endometrial defect alternative therapeutic protocols such as the use of advanced cellular therapies may be used, to restore the women’s fertility.
Publish Date	2025-04-23 03:33
Citation	<p>Mallis P. MicroRNAs derived from the hypoxic endometrial epithelial cells effectively regulate the regenerative properties of mesenchymal stromal cells. <i>World J Stem Cells</i> 2025; 17(4): 102482</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i4/102482.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i4.102482

Full Article (PDF)	WJSC-17-102482-with-cover.pdf
Manuscript File	102482_Auto_Edited_020802.docx
Answering Reviewers	102482-answering-reviewers.pdf
Audio Core Tip	102482-audio.aac
Conflict-of-Interest Disclosure Form	102482-conflict-of-interest-statement.pdf
Copyright License Agreement	102482-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	102482-non-native-speakers.pdf
Peer-review Report	102482-peer-reviews.pdf
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Scientific Editor Work List	102482-scientific-editor-work-list.pdf
CrossCheck Report	102482-crosscheck-report.pdf