Publication Name	World Journal of Orthopedics
Manuscript ID	102520
Country	Brazil

Received	2024-10-21 09:18
Peer-Review Started	2024-10-21 09:18
To Make the First Decision
Return for Revision	2024-12-24 02:54
Revised	2025-01-06 20:52
Second Decision	2025-02-11 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-12 09:40
Articles in Press	2025-02-12 09:40
Publication Fee Transferred	2025-01-08 19:58
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-05 03:47
Publish the Manuscript Online	2025-03-12 05:57

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Meta-Analysis
Article Title	Denosumab regimens in the treatment of giant cell tumor of bone: A systematic review with meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Bruno G Barreto, Claudio Santili, Alex Guedes, Fernando D Moreira and Claudio Luiz DSL Paz
ORCID	Author(s) ORCID Number Bruno G Barreto http://orcid.org/0000-0002-4722-7574 Alex Guedes http://orcid.org/0000-0001-7013-7107
Funding Agency and Grant Number
Corresponding Author	Bruno G Barreto, MD, Professor, Department of Orthopedics and Traumatology, Hospital Aristides Maltez, av. Dom João VI, 332, Salvador 40285-001, Bahia, Brazil. bbarreto1978@gmail.com
Key Words	Bone neoplasms; Denosumab; Outcome assessment health care; Giant cell tumor of bone; Systematic review
Core Tip	This systematic review with meta-analysis of proportions sought to evaluate the effectiveness of various denosumab-containing therapeutic regimens in the treatment of giant cell tumor of bone in terms of clinical outcomes, imaging response (IR), local recurrence (LR), and adverse events. Denosumab proved to be effective in inducing clinical response and IR, without impact on LR, regardless of the regimen and number of doses.
Publish Date	2025-03-12 05:57
Citation	<p>Barreto BG, Santili C, Guedes A, Moreira FD, Paz CLD. Denosumab regimens in the treatment of giant cell tumor of bone: A systematic review with meta-analysis. <i>World J Orthop</i> 2025; 16(3): 102520</p>
URL	https://www.wjgnet.com/2218-5836/full/v16/i3/102520.htm
DOI	https://dx.doi.org/10.5312/wjo.v16.i3.102520

Full Article (PDF)	WJO-16-102520-with-cover.pdf
PRISMA 2009 Checklist	102520-PRISMA-2009-Checklist.pdf
Manuscript File	102520_Auto_Edited_060147.docx
Answering Reviewers	102520-answering-reviewers.pdf
Audio Core Tip	102520-audio.m4a
Biostatistics Review Certificate	102520-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	102520-conflict-of-interest-statement.pdf
Copyright License Agreement	102520-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	102520-non-native-speakers.pdf
Supplementary Material	102520-supplementary-material.pdf
Peer-review Report	102520-peer-reviews.pdf
Scientific Misconduct Check	102520-scientific-misconduct-check.png
Scientific Editor Work List	102520-scientific-editor-work-list.pdf
CrossCheck Report	102520-crosscheck-report.pdf