Publication Name	World Journal of Diabetes
Manuscript ID	102526
Country	China

Received	2024-10-21 03:01
Peer-Review Started	2024-10-23 15:48
To Make the First Decision
Return for Revision	2024-12-17 02:33
Revised	2024-12-30 19:15
Second Decision	2025-01-08 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-08 06:03
Articles in Press	2025-01-08 06:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-13 00:50
Publish the Manuscript Online	2025-01-21 09:27

ISSN	1948-9358 (online)
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Category	Endocrinology & Metabolism
Manuscript Type	Editorial
Article Title	Premixed insulin: Advantages, disadvantages, and future
Manuscript Source	Invited Manuscript
All Author List	Yan Xia, Yun Hu and Jian-Hua Ma
ORCID	Author(s) ORCID Number Yun Hu http://orcid.org/0000-0002-4477-3641 Jian-Hua Ma http://orcid.org/0000-0001-9383-2559
Funding Agency and Grant Number
Corresponding Author	Jian-Hua Ma, MD, Professor, Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, No. 32 Gongqingtuan Road, Nanjing 210000, Jiangsu Province, China. majianhua@china.com
Key Words	Premixed insulin; Blood glucose control; Insulin antibodies; Diabetes; Glucose-lowering therapy
Core Tip	Premixed insulin improved patient adherence because of its simplified treatment regimens, fewer injections, and low price. Therefore, premixed insulin is widely used, especially in developed countries. However, patients receiving premixed insulin commonly have less satisfactory blood glucose control. The fixed ratio of premixed insulin usually fails to meet the nuanced demands of individualized glucose-lowering therapy. Moreover, aberrant local absorption and potential systemic autoimmune responses of premixed insulin may further affect glycemic control. New insulin formulations offer improved blood glucose control, weight management, and reduced hypoglycemia. Further studies are needed to guide the optimization of insulin use through individualized treatment approaches or to mitigate the side effects of premixed insulin through novel drug combinations.
Publish Date	2025-01-21 09:27
Citation	<p>Xia Y, Hu Y, Ma JH. Premixed insulin: Advantages, disadvantages, and future. <i>World J Diabetes</i> 2025; 16(3): 102526</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i3/102526.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i3.102526

Full Article (PDF)	WJD-16-102526-with-cover.pdf
Manuscript File	102526_Auto_Edited_004536.docx
Answering Reviewers	102526-answering-reviewers.pdf
Audio Core Tip	102526-audio.m4a
Conflict-of-Interest Disclosure Form	102526-conflict-of-interest-statement.pdf
Copyright License Agreement	102526-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	102526-non-native-speakers.pdf
Peer-review Report	102526-peer-reviews.pdf
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Scientific Editor Work List	102526-scientific-editor-work-list.pdf
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CrossCheck Report	102526-crosscheck-report.pdf