| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Observational Study |
| Article Title |
Serum homocysteine showed potential association with cognition and abnormal gut microbiome in major depressive disorder
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chen-Chen Xu, Wen-Xuan Zhao, Yu Sheng, Ya-Jun Yun, Ting Ma, Ning Fan, Jia-Qi Song, Jun Wang and Qi Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Wuxi Municipal Health Commission Youth Fund Project |
No. Q202268 |
| Wuxi Scientific and technological breakthrough of “Light of the Taihu Lake” (Basic Research) |
No. K20221039 |
| Jiangsu Shuangchuang Doctoral Program |
No. JSSCBS20221991 |
| Beijing Municipal Administration of Hospital Incubating Program |
No. PX2023070 |
| Beijing Municipal Administration of Hospital Incubating Program |
No. PX2024072 |
| Capital’s Funds for Health Improvement and Research |
No. SF2024-4-2134 |
| Beijing Hospitals Authority Youth Program |
No. QML20232003 |
| Top Talent Support Program for young and middle-aged people of Wuxi Health Committee |
No. HB2023089 |
|
| Corresponding Author |
Qi Zhang, PhD, Department of Psychiatry, The Affiliated Wuxi Mental Health Center of Nanjing Medical University, No. 156 Qianrong Road, Binhu District, Wuxi 214151, Jiangsu Province, China. 1811110636@bjmu.edu.cn |
| Key Words |
Homocysteine; Microbiome; Intestinal flora; Gut microbiota; Gut–brain axis; Major depressive disorder; Cognitive function; Cognitive impairment |
| Core Tip |
Cognitive impairment is common in patients with depression, who often exhibit elevated levels of homocysteine (Hcy) and abnormalities in gut microbiome. However, to date, no research has systematically investigated the relationship between Hcy, the microbiome, and cognition in depressive patients. Our study integrates results from functional predictive analysis, microbiome data, and clinical scale assessments, revealing a close association between Hcy levels, cognitive function, and gut microbiome, in major depressive disorder. These findings may contribute to elucidating the physiological and pathological mechanisms underlying cognitive deficits in depression, further supporting the brain-gut axis theory, and providing evidence for gut- microbiome-based therapeutic strategies. |
| Publish Date |
2025-02-26 04:37 |
| Citation |
<p>Xu CC, Zhao WX, Sheng Y, Yun YJ, Ma T, Fan N, Song JQ, Wang J, Zhang Q. Serum homocysteine showed potential association with cognition and abnormal gut microbiome in major depressive disorder. <i>World J Psychiatry</i> 2025; 15(3): 102567</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i3/102567.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i3.102567 |
