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7/18/2025 3:29:23 PM | Browse: 49 | Download: 296
Publication Name World Journal of Critical Care Medicine
Manuscript ID 102577
Country Greece
Received
2024-10-23 04:05
Peer-Review Started
2024-10-23 04:05
First Decision by Editorial Office Director
2025-02-25 07:49
Return for Revision
2025-02-25 07:49
Revised
2025-03-17 11:34
Publication Fee Transferred
Second Decision by Editor
2025-03-27 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-03-27 07:30
Articles in Press
2025-03-27 07:30
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-05-29 14:09
Publish the Manuscript Online
2025-07-18 15:29
ISSN 2220-3141(online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Minireviews
Article Title Critical illness-implications of non-thyroidal illness syndrome and thyroxine therapy
Manuscript Source Invited Manuscript
All Author List Christos Savvidis, Dimitra Ragia, Efthymia Kallistrou, Eleni Kouroglou, Vasiliki Tsiama, Stella Proikaki, Konstantinos Belis and Ioannis Ilias
ORCID
Author(s) ORCID Number
Christos Savvidis http://orcid.org/0000-0002-0188-1685
Ioannis Ilias http://orcid.org/0000-0001-5718-7441
Funding Agency and Grant Number
Corresponding Author Ioannis Ilias, MD, PhD, Department of Endocrinology, Hippocration General Hospital, 63 Evrou Str., Athens GR-11527, Greece. iiliasmd@yahoo.com
Key Words L-thyroxine; Triiodothyronine; Thyroid hormone therapy; Nonthyroidal illness syndrome; Thyroxine therapy; Thyroid hormones; Critical illness; Hypothalamus-pituitary-thyroid axis
Core Tip Nonthyroidal illness syndrome, common in critically ill patients, disrupts thyroid function through cytokine-driven mechanisms. While thyroid hormone replacement therapy shows potential in certain subgroups, such as in patients with septic shock, evidence on its benefits remains inconclusive. Future research should focus on individualized treatment approaches to improve outcomes.
Publish Date 2025-07-18 15:29
Citation

Savvidis C, Ragia D, Kallistrou E, Kouroglou E, Tsiama V, Proikaki S, Belis K, Ilias I. Critical illness-implications of non-thyroidal illness syndrome and thyroxine therapy. World J Crit Care Med 2025; 14(3): 102577

URL https://www.wjgnet.com/2220-3141/full/v14/i3/102577.htm
DOI https://dx.doi.org/10.5492/wjccm.v14.i3.102577
Full Article (PDF) WJCCM-14-102577-with-cover.pdf
Manuscript File 102577_Auto_Edited_125526.docx
Answering Reviewers 102577-answering-reviewers.pdf
Audio Core Tip 102577-audio.mp3
Conflict-of-Interest Disclosure Form 102577-conflict-of-interest-statement.pdf
Copyright License Agreement 102577-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 102577-non-native-speakers.pdf
Peer-review Report 102577-peer-reviews.pdf
Scientific Misconduct Check 102577-scientific-misconduct-check.png
Scientific Editor Work List 102577-scientific-editor-work-list.pdf
CrossCheck Report 102577-crosscheck-report.pdf