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Articles Published Processes
3/25/2025 4:19:46 PM | Browse: 133 | Download: 726
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Received |
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2024-10-24 04:56 |
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Peer-Review Started |
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2024-10-24 04:56 |
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First Decision by Editorial Office Director |
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2024-12-17 10:25 |
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Return for Revision |
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2024-12-17 10:25 |
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Revised |
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2025-01-07 03:41 |
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Publication Fee Transferred |
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2025-01-16 08:10 |
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Second Decision by Editor |
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2025-02-25 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-02-25 08:06 |
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Articles in Press |
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2025-02-25 08:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-03-07 07:27 |
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Publish the Manuscript Online |
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2025-03-25 16:19 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Centromere protein A knockdown inhibits rectal cancer through O6-methylguanine DNA methyltransferase/protein tyrosine phosphatase nonreceptor type 4 axis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ming-Jie Xin and Yong Yuan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ming-Jie Xin, Medical College, Henan Vocational University of Science and Technology, No. 6 East Section of Wenchang Avenue, Zhoukou 466000, Henan Province, China. xinmingjie_1985@126.com |
| Key Words |
Rectal cancer; Centromere protein A; O6-methylguanine DNA methyltransferase; Protein tyrosine phosphatase nonreceptor type 4; Proliferation; Invasion |
| Core Tip |
This study suggested that Centromere protein A (CENPA) was upregulated in rectal cancer tissues and cell lines. CENPA overexpression promoted proliferation, invasion and epithelial-mesenchymal transition, and inhibited apoptosis in rectal cancer cells. Whereas CENPA knockdown showed the opposite results. Additionally, CENPA knockdown inhibited xenograft tumor growth in vivo. Mechanistically, CENPA inhibited O6-methylguanine DNA methyltransferase (MGMT) expression by promoting DNA methyltransferase 1-mediated MGMT promoter methylation. MGMT interacted with protein tyrosine phosphatase nonreceptor type 4 (PTPN4) and increased PTPN4 protein stability. CENPA knockdown inhibited rectal cancer progression through regulating the MGMT/PTPN4 axis. |
| Publish Date |
2025-03-25 16:19 |
| Citation |
Xin MJ, Yuan Y. Centromere protein A knockdown inhibits rectal cancer through O6-methylguanine DNA methyltransferase/protein tyrosine phosphatase nonreceptor type 4 axis. World J Gastrointest Oncol 2025; 17(4): 102619 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i4/102619.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i4.102619 |
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