| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Kinesin family member 14 expression and its clinical implications in colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kai Qin, Jia-Yuan Luo, Da-Tong Zeng, Wan-Ying Huang, Bin Li, Qi Li, Yan-Ting Zhan, Rong-Quan He, Wei-Jian Huang, Gang Chen, Zu-Yuan Chen, Bang-Teng Chi, Yu-Xing Tang, Rui-Xue Tang and Hui Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Shandong Province |
ZR2020QH185 |
| Scientific Research Nurturing Fund of The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital |
QYPY2020NSFC0803 |
| Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project |
Z-A20220415 |
| Guangxi Medical University Teacher Teaching Ability Development Project |
2022JFA02 |
| Guangxi Medical University Undergraduate Education and Teaching Reform Project |
2023Y05 |
|
| Corresponding Author |
Hui Li, Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. lihui_gxmu@163.com |
| Key Words |
Colorectal cancer; Kinesin family member 14; Nitidine chloride; Molecular docking; Standardized mean difference |
| Core Tip |
This study evaluates the clinical and pathological significance of Kinesin family member 14 (KIF14) in colorectal cancer (CRC) and explores its interaction with nitidine chloride (NC) as a potential therapeutic target. High KIF14 expression in CRC was confirmed through immunohistochemistry and multiplatform mRNA analysis, with significant diagnostic accuracy. Clustered regularly interspaced short palindromic repeats screening and single-cell sequencing validated KIF14’s role in CRC cell growth. Survival analysis highlighted KIF14’s prognostic value. Molecular docking revealed a strong binding affinity between NC and KIF14, suggesting that KIF14 is a promising target for NC in CRC treatment. |
| Publish Date |
2025-02-14 10:33 |
| Citation |
<p>Qin K, Luo JY, Zeng DT, Huang WY, Li B, Li Q, Zhan YT, He RQ, Huang WJ, Chen G, Chen ZY, Chi BT, Tang YX, Tang RX, Li H. Kinesin family member 14 expression and its clinical implications in colorectal cancer. <i>World J Gastrointest Oncol</i> 2025; 17(3): 102696</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i3/102696.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i3.102696 |
