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Articles Published Processes
3/6/2025 10:23:32 AM | Browse: 32 | Download: 59
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Received |
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2024-10-28 06:52 |
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Peer-Review Started |
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2024-10-28 06:53 |
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To Make the First Decision |
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Return for Revision |
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2025-01-08 11:59 |
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Revised |
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2025-01-21 09:51 |
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Second Decision |
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2025-02-08 02:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-02-08 10:24 |
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Articles in Press |
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2025-02-08 10:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-02-14 03:36 |
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Publish the Manuscript Online |
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2025-03-06 10:23 |
| ISSN |
2222-0682 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Biological and translational attributes of mitochondrial DNA copy number: Laboratory perspective to clinical relevance
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Deepak Parchwani, Ragini Singh and Digisha Patel |
| ORCID |
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| Corresponding Author |
Deepak Parchwani, PhD, Professor, Department of Biochemistry, All India Institute of Medical Sciences, AIIMS Rajkot, Village Khandheri, Tehsil Paddhari, Rajkot 360001, India. drdeepakparchwani@yahoo.com |
| Key Words |
Mitochondrial DNA copy number; Mitochondrial DNA; Quantitative polymerase chain reaction; Cancer; Neurodegenerative disease; Aging |
| Core Tip |
This review highlights the critical biological and translational significance of mitochondrial DNA (mtDNA) copy number (mtDNAcn) variations and emphasizes their implications in both laboratory diagnostics and clinical settings. By exploring the mechanisms underlying mtDNA replication, the association of mtDNAcn with various diseases, and its potential as a biomarker for mitochondrial dysfunction, we underscore the need for standardized methodologies for measuring mtDNAcn. This perspective aims to bridge the gap between basic research and clinical applications by facilitating the integration of mtDNAcn assessments into routine diagnostic practices and therapeutic strategies for mitochondria-related diseases. |
| Publish Date |
2025-03-06 10:23 |
| Citation |
<p>Parchwani D, Singh R, Patel D. Biological and translational attributes of mitochondrial DNA copy number: Laboratory perspective to clinical relevance. <i>World J Methodol</i> 2025; 15(3): 102709</p> |
| URL |
https://www.wjgnet.com/2222-0682/full/v15/i3/102709.htm |
| DOI |
https://dx.doi.org/10.5662/wjm.v15.i3.102709 |
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