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Articles Published Processes
6/13/2025 11:47:51 AM | Browse: 42 | Download: 394
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Received |
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2024-10-28 03:14 |
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Peer-Review Started |
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2024-10-30 01:07 |
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First Decision by Editorial Office Director |
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2025-01-08 07:22 |
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Return for Revision |
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2025-01-08 07:22 |
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Revised |
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2025-01-20 22:33 |
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Publication Fee Transferred |
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2025-01-23 21:10 |
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Second Decision by Editor |
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2025-03-21 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-03-28 06:26 |
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Articles in Press |
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2025-03-28 06:26 |
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Edit the Manuscript by Language Editor |
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2025-04-16 04:00 |
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Typeset the Manuscript |
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2025-06-06 02:17 |
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Publish the Manuscript Online |
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2025-06-13 11:47 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Basic Study |
| Article Title |
Mechanism of trypsin-mediated differentiation of pancreatic progenitor cells into functional islet-like clusters
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ling Gao, Jia-Shuang Lai, Han Chen, Li-Xia Qian, Wan-Jin Hong and Liang-Cheng Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82073908 |
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| Corresponding Author |
Liang-Cheng Li, Associate Professor, PhD, School of Pharmaceutical Sciences, Xiamen University, No. 4221-115 Xiangan South Road, Xiangan District, Xiamen 361102, Fujian Province, China. lchli2013@xmu.edu.cn |
| Key Words |
Endogenous islet β-cell regeneration; Trypsin; Pancreatic cancer cell line-1; Pancreatic islet progenitor cell; E-cadherin; Alpha-catenin |
| Core Tip |
Induced by trypsin, pancreatic cancer cell line-1 differentiated into insulin-producing cells. Loss of E-cadherin, αE-catenin and casein kinase-1γ3 (CK1γ3) blocked trypsin-induced differentiation. Stimulated by trypsin hydrolysis, E-cadherin recruited CK1γ3. CK1γ3 phosphorylated αE-catenin specific site Ser655/Thr658. |
| Publish Date |
2025-06-13 11:47 |
| Citation |
Gao L, Lai JS, Chen H, Qian LX, Hong WJ, Li LC. Mechanism of trypsin-mediated differentiation of pancreatic progenitor cells into functional islet-like clusters. World J Diabetes 2025; 16(6): 102727 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i6/102727.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i6.102727 |
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