| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Review |
| Article Title |
Stem cell therapy for intervertebral disc degeneration: Clinical progress with exosomes and gene vectors
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Peng Li, Han Li, Yu-Hua Ruan, Peng Wang, Meng-Ting Zhu, Wei-Ping Fu, Rui-Bo Wang, Xiao-Dong Tang, Qi Zhang, Sen-Li Li, He Yin, Cheng-Jin Li, Yi-Gong Tian, Rui-Ning Han, Yao-Bin Wang and Chang-Jiang Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Henan Province Key Research and Development Program |
231111311000 |
| Henan Provincial Science and Technology Research Project |
232102310411 |
| Henan Province Medical Science and Technology Key Project |
LHGJ20220566, LHGJ20240365 |
| Henan Province Medical Education Research Project |
WJLX2023079 |
| Zhengzhou Medical and Health Technology Innovation Guidance Program |
2024YLZDJH022 |
|
| Corresponding Author |
Chang-Jiang Zhang, Chief Physician, MD, Professor, Second Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, No. 3 Kangfu Qianjie, Erqi District, Zhengzhou 450052, Henan Province, China. changjiangzhang1968@outlook.com |
| Key Words |
Exosomes; Extracellular matrix repair; Gene vector system; Hypoxic environment; Intervertebral disc degeneration; Mesenchymal stem cells; Regenerative medicine; Stem cell therapy |
| Core Tip |
The application of stem cell therapy in intervertebral disc degeneration has shown significant regenerative potential. Through differentiation, paracrine effects, and immunomodulation, stem cells can repair damaged extracellular matrix and slow the degenerative process. Emerging technologies such as exosomes and gene vector systems further enhance the therapeutic effects of stem cells, improving cell survival rates and regenerative capabilities. However, the long-term survival of stem cells in a hypoxic environment, the optimal injection dosage, and their long-term safety still requires further investigation. Future interdisciplinary collaboration will drive the clinical translation of stem cell therapy, making it a standard option for the treatment of intervertebral disc degeneration. |
| Publish Date |
2025-04-23 03:33 |
| Citation |
<p>Li ZP, Li H, Ruan YH, Wang P, Zhu MT, Fu WP, Wang RB, Tang XD, Zhang Q, Li SL, Yin H, Li CJ, Tian YG, Han RN, Wang YB, Zhang CJ. Stem cell therapy for intervertebral disc degeneration: Clinical progress with exosomes and gene vectors. <i>World J Stem Cells</i> 2025; 17(4): 102945</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i4/102945.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i4.102945 |
