Publication Name	World Journal of Diabetes
Manuscript ID	102994
Country	China

Received	2024-11-05 06:11
Peer-Review Started	2024-11-20 02:01
To Make the First Decision
Return for Revision	2025-01-08 07:39
Revised	2025-02-09 15:48
Second Decision	2025-03-12 09:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
Articles in Press	2025-03-19 08:50
Publication Fee Transferred	2025-02-26 07:45
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-14 02:31
Publish the Manuscript Online	2025-04-25 07:54

ISSN	1948-9358 (online)
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	TERT/FOXO1 signaling promotes islet β-cell dysfunction in type 2 diabetes mellitus by regulating ATG9A-mediated autophagy
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Tian Lei, Xiang-Fen Chen, Sheng Qiu, Jia-Ying Tang, Shan Geng, Gang-Yi Yang and Qi-Nan Wu
ORCID	Author(s) ORCID Number Qi-Nan Wu http://orcid.org/0009-0000-7001-4836
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82000792 General Project of Chongqing Natural Science Foundation CSTB2023NSCQ-MSX0246 and CSTB2022NSCQ-MSX1271 Research Project of the State Administration of Traditional Chinese Medicine on collaborative chronic disease management of traditional Chinese Medicine and Western Medicine CXZH2024087 Science and Health Joint Project of Dazu District Science and Technology Bureau DZKJ2024JSYJ-KWXM1002
Corresponding Author	Qi-Nan Wu, Chief Physician, MD, PhD, Professor, Department of Endocrinology, The Affiliated Dazu’s Hospital of Chongqing Medical University, The People's Hospital of Dazu, No. 1073 Second Ring Road, Dazu District, Chongqing 402360, China. 152299@hospital.cqmu.edu.cn
Key Words	TERT; TERT; ATG9A; Autophagy; Islet β-cells; Type 2 diabetes mellitus
Core Tip	Our research elucidated the mechanism by which TERT/FOXO1 affects high glucose-induced dysfunction in islet β-cells via the regulation of ATG9A-mediated autophagy. It revealed the mechanism by which TERT/FOXO1 mediates ATG9A to inhibit autophagy in mouse’s β cells. These findings indicated that FOXO1 is a potential target for the treatment of type 2 diabetes mellitus (T2DM) by acting as an autophagy regulator, deepening the understanding of the autophagy mechanisms involved in the regulation of β-cell function in the context of T2DM.
Publish Date	2025-04-25 07:54
Citation	<p>Lei XT, Chen XF, Qiu S, Tang JY, Geng S, Yang GY, Wu QN. TERT/FOXO1 signaling promotes islet β-cell dysfunction in type 2 diabetes mellitus by regulating ATG9A-mediated autophagy. <i>World J Diabetes</i> 2025; 16(5): 102994</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i5/102994.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i5.102994

Full Article (PDF)	WJD-16-102994-with-cover.pdf
The ARRIVE Guidelines	102994-The-ARRIVE-Guidelines.pdf
Manuscript File	102994_Auto_Edited_081200.docx
Answering Reviewers	102994-answering-reviewers.pdf
Audio Core Tip	102994-audio.mp4
Biostatistics Review Certificate	102994-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	102994-conflict-of-interest-statement.pdf
Copyright License Agreement	102994-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	102994-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	102994-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	102994-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	102994-non-native-speakers.pdf
Supplementary Material	102994-supplementary-material.pdf
Peer-review Report	102994-peer-reviews.pdf
Scientific Misconduct Check	102994-scientific-misconduct-check.png
Scientific Editor Work List	102994-scientific-editor-work-list.pdf
CrossCheck Report	102994-crosscheck-report.pdf