Publication Name	World Journal of Gastroenterology
Manuscript ID	10307
Country	India

Received	2014-03-25 21:27
Peer-Review Started	2014-03-26 08:26
To Make the First Decision	2014-04-28 14:14
Return for Revision	2014-05-03 19:35
Revised	2014-05-08 02:09
Second Decision	2014-06-13 12:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-13 12:23
Articles in Press	2014-06-13 13:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-10-17 15:52
Publish the Manuscript Online	2014-10-29 19:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Chronic Liver Failure-Sequential Organ Failure Assessment is better than the Asia-Pacific Association for the Study of Liver criteria for defining acute-on-chronic liver failure and predicting outcome
Manuscript Source	Invited Manuscript
All Author List	Radha K Dhiman, Swastik Agrawal, Tarana Gupta, Ajay Duseja and Yogesh Chawla
Funding Agency and Grant Number
Corresponding Author	Radha K Dhiman, MD, DM, FAMS, FACG, Professor, Department of Hepatology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. rkpsdhiman@hotmail.com
Key Words	Cirrhosis; Acute decompensation; Mortality; Prognosis; Acute on chronic liver failure
Core Tip	The most common acute precipitant for acute-on-chronic liver failure (ACLF) is infection. The Chronic Liver Failure-Sequential Organ Failure Assessment (CLIF-SOFA) criteria is better than Asia-Pacific Association for the Study of Liver criteria in defining ACLF as the CLIF-SOFA criteria identifies patients with a high likelihood of mortality who could benefit from liver transplantation or inclusion into trials of newer therapeutic modalities. Mortality increases with increasing grades of ACLF based on number of organ failures in Asian-Indian patients similar to the results seen in the European population. Also, the multi-organ failure CLIF-SOFA score is better than liver specific Model for End-Stage Liver Disease and Child-Pugh scores, suggesting that ACLF leads to multi-organ failure and is not limited to the liver.
Publish Date	2014-10-29 19:34
Citation	Dhiman RK, Agrawal S, Gupta T, Duseja A, Chawla Y. Chronic Liver Failure-Sequential Organ Failure Assessment is better than the Asia-Pacific Association for the Study of Liver criteria for defining acute-on-chronic liver failure and predicting outcome. World J Gastroenterol 2014; 20(40): 14934-14941
URL	http://www.wjgnet.com/1007-9327/full/v20/i40/14934.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i40.14934

Full Article (PDF)	WJG-20-14934.pdf
Full Article (Word)	WJG-20-14934.doc
Manuscript File	10307-Review.doc
Answering Reviewers	10307-Answering reviewers.pdf
Copyright License Agreement	10307-Copyright assignment.pdf
Peer-review Report	10307-Peer review.pdf
Scientific Misconduct Check	10307-CorssCheck.jpg
Scientific Editor Work List	10307-Scientific editor work list.pdf