Publication Name	World Journal of Gastroenterology
Manuscript ID	10312
Country	China

Received	2014-03-26 14:26
Peer-Review Started	2014-03-26 17:27
First Decision by Editorial Office Director
Return for Revision	2014-06-03 12:41
Revised	2014-06-05 00:00
Publication Fee Transferred
Second Decision by Editor	2014-07-30 10:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-07-30 10:14
Articles in Press	2014-07-30 10:38
Edit the Manuscript by Language Editor	2014-08-22 07:54
Typeset the Manuscript	2014-11-28 09:23
Publish the Manuscript Online	2014-12-18 17:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Is concomitant radiotherapy necessary with gemcitabine-based chemotherapy in pancreatic cancer?
Manuscript Source	Unsolicited Manuscript
All Author List	Xin Zhang, He-Jing Huang, Dan Feng, De-Jun Yang, Chang-Ming Wang and Qing-Ping Cai
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81402359 National Natural Science Foundation of China 81372670
Corresponding Author	Qing-Ping Cai, Professor, Department of Gastrointestinal Surgery, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai 200003, China. caiqp1969@hotmail.com
Key Words	Pancreatic cancer; Radiotherapy; Chemotherapy; Gemcitabine; Meta-analysis
Core Tip	We performed this meta-analysis to evaluate the efficacy and safety of gemcitabine plus radiotherapy compared with gemcitabine alone for pancreatic cancer (PC). A total of 336 participants from four original studies were included. Gemcitabine plus radiotherapy resulted in comparable survival results to gemcitabine alone. Moreover, concomitant radiotherapy was associated with a significantly higher incidence of severe (grade 3 or greater) toxicities, mainly anemia, leukocytopenia, thrombocytopenia, anorexia, nausea/vomiting, and asthenia/fatigue. Therefore, radiotherapy is not beneficial with gemcitabine-based chemotherapy for PC. Further exploration for better radiotherapy approaches and therapeutic regimens in the treatment of PC is still warranted.
Publish Date	2014-12-18 17:08
Citation	Zhang X, Huang HJ, Feng D, Yang DJ, Wang CM, Cai QP. Is concomitant radiotherapy necessary with gemcitabine-based chemotherapy in pancreatic cancer? World J Gastroenterol 2014; 20(46): 17648-17655
URL	http://www.wjgnet.com/1007-9327/full/v20/i46/17648.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i46.17648

Full Article (PDF)	WJG-20-17648.pdf
Full Article (Word)	WJG-20-17648.doc
Manuscript File	10312-Review.doc
Answering Reviewers	10312-Answering reviewers.pdf
Copyright License Agreement	10312-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	10312-Language certificate.pdf
Peer-review Report	10312-Peer review.pdf
Scientific Misconduct Check	10312-CorssCheck.jpg
Scientific Editor Work List	10312-Scientific editor work list.pdf