Publication Name	World Journal of Gastroenterology
Manuscript ID	103133
Country	China

Received	2024-11-11 03:00
Peer-Review Started	2024-11-11 03:00
To Make the First Decision
Return for Revision	2024-12-21 22:10
Revised	2025-01-04 12:40
Second Decision	2025-02-05 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-05 03:21
Articles in Press	2025-02-05 03:21
Publication Fee Transferred	2025-01-11 05:43
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-02-17 07:28
Publish the Manuscript Online	2025-02-26 04:21

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	SEL1L-mediated endoplasmic reticulum associated degradation inhibition suppresses proliferation and migration in Huh7 hepatocellular carcinoma cells
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Nan Chen, Li Wang, Yu-Xin He, Xiao-Wei Sun, Long-Jiao Cheng, Ya-Nan Li, Sei Yoshida and Zhong-Yang Shen
ORCID	Author(s) ORCID Number Sei Yoshida http://orcid.org/0000-0002-4771-3900 Zhong-Yang Shen http://orcid.org/0009-0000-2212-4539
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82241219 National Natural Science Foundation of China No. 82127808 National Natural Science Foundation of China No. 81921004 Shenzhen Science and Technology Program No. JCYJ20210324120813037
Corresponding Author	Zhong-Yang Shen, MD, Professor, School of Medicine, Nankai University, No. 94 Fukang Road, Nankai District, Tianjin 300071, China. zhongyangshen@nankai.edu.cn
Key Words	Hepatocellular carcinoma; Endoplasmic reticulum stress; Endoplasmic reticulum-associated protein degradation; SEL1L; EXT2
Core Tip	The endoplasmic reticulum-associated degradation (ERAD) inhibitor suppressed cell proliferation and migration and promoted apoptosis. SEL1L-HRD1 significantly influenced Huh7 cell growth. SEL1L knockout suppressed tumor cell proliferation and migration, and enhanced apoptosis. Mass spectrometry revealed EXT2 is a primary substrate of ERAD. SEL1L knockout significantly increased the protein expression of EXT2, whereas EXT2 knockdown partially restored the effect of SEL1L knockout. In conclusion, this study showed the function and possible mechanisms of ERAD in hepatocellular carcinoma, providing new insights into more effective treatment and strategies for liver cancer.
Publish Date	2025-02-26 04:21
Citation	<p>Chen JN, Wang L, He YX, Sun XW, Cheng LJ, Li YN, Yoshida S, Shen ZY. SEL1L-mediated endoplasmic reticulum associated degradation inhibition suppresses proliferation and migration in Huh7 hepatocellular carcinoma cells. <i>World J Gastroenterol</i> 2025; 31(10): 103133</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i10/103133.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i10.103133

Full Article (PDF)	WJG-31-103133-with-cover.pdf
The ARRIVE Guidelines	103133-The-ARRIVE-Guidelines.pdf
Manuscript File	103133_Auto_Edited_070843.docx
Answering Reviewers	103133-answering-reviewers.pdf
Audio Core Tip	103133-audio.mp3
Biostatistics Review Certificate	103133-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	103133-conflict-of-interest-statement.pdf
Copyright License Agreement	103133-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	103133-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	103133-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	103133-non-native-speakers.pdf
Supplementary Material	103133-supplementary-material.pdf
Peer-review Report	103133-peer-reviews.pdf
Scientific Misconduct Check	103133-scientific-misconduct-check.png
Scientific Editor Work List	103133-scientific-editor-work-list.pdf
CrossCheck Report	103133-crosscheck-report.png
CrossCheck Report	103133-crosscheck-report.pdf