| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jonathan R Strosberg, George A Fisher, Al B Benson, Lowell B Anthony, Bulent Arslan, John F Gibbs, Edward Greeno, Renuka V Iyer, Michelle K Kim, William J Maples, Philip A Philip, Edward M Wolin, Dasha Cherepanov and Michael S Broder |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ 07936-1080, United States |
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| Corresponding Author |
Michael S Broder, MD, MSHS, Partnership for Health Analytic Research, LLC, 280 South Beverly Drive, Suite 404, Beverly Hills, CA 90212, United States. mbroder@pharllc.com |
| Key Words |
Unresectable; Neuroendocrine carcinomas; Neuroendocrine tumors; Well-differentiated; Grade 1; Grade 2; Low tumors; Intermediate tumors; Pancreatic neoplasms; Treatment; Consensus; Delphi technique; Expert testimony |
| Core Tip |
Using the RAND/UCLA modified Delphi process, physician experts obtained consensus on the appropriateness of various medical therapies in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors. Consensus statements were: (1) it is appropriate to use somatostatin analogs as first-line therapy in patients with hormonally-functional tumors and may be appropriate in asymptomatic patients; (2) it is appropriate to use everolimus, sunitinib, or cytotoxic chemotherapy as first-line therapy in patients with symptomatic or progressive tumors; and (3) beyond first-line, these same agents can be used. In patients with uncontrolled secretory symptoms, octreotide-LAR can be titrated up to 60 mg/4 wk or up to 40 mg/3 or 4 wk. |
| Publish Date |
2015-02-28 17:07 |
| Citation |
Strosberg JR, Fisher GA, Benson AB, Anthony LB, Arslan B, Gibbs JF, Greeno E, Iyer RV, Kim MK, Maples WJ, Philip PA, Wolin EM, Cherepanov D, Broder MS. Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors. World J Gastroenterol 2015; 21(8): 2450-2459 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i8/2450.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i8.2450 |
