| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Role of transient elastography in the diagnosis and prognosis of Fontan-associated liver disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Marta Cuadros, Marta Abadía, Pilar Castillo, María Dolores Martín-Arranz, Nerea Gonzalo, Miriam Romero, Araceli García-Sánchez, Javier García-Samaniego, Antonio Olveira, José Ruiz-Cantador, Óscar González-Fernández, Ines Ponz, Pablo Merás, Carlos Merino, Adriana Rodríguez-Chaverri, Enrique Balbacid and Consuelo Froilán |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Marta Cuadros, MD, Department of Gastroenterology and Hepatology, Hospital Universitario La Paz, Paseo de la Castellana, 261, Madrid 28046, Spain. cuadrosmartinez@gmail.com |
| Key Words |
Transient elastography; Liver stiffness; Fontan-associated liver disease; Fontan; Congenital heart disease; Single ventricle |
| Core Tip |
There was a significant association between liver stiffness measurement (LSM) by transient elastography (TE) and Fontan-associated liver disease (FALD). We obtained areas under the curve (AUC) of 0.905 for FALD and 0.764 for advanced FALD. The optimal cut-off values were 20 kPa for FALD and 25 kPa for advanced FALD. An algorithm for FALD was proposed based on LSM by TE and elapsed time since Fontan surgery with an AUC of 0.877. We also demonstrated an association between LSM by TE and clinically relevant events (heart or heart-liver transplantation indication, hepatocellular carcinoma, and all-cause mortality). |
| Publish Date |
2025-03-13 10:11 |
| Citation |
<p>Cuadros M, Abadía M, Castillo P, Martín-Arranz MD, Gonzalo N, Romero M, García-Sánchez A, García-Samaniego J, Olveira A, Ruiz-Cantador J, González-Fernández Ó, Ponz I, Merás P, Merino C, Rodríguez-Chaverri A, Balbacid E, Froilán C. Role of transient elastography in the diagnosis and prognosis of Fontan-associated liver disease. <i>World J Gastroenterol</i> 2025; 31(11): 103178</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i11/103178.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i11.103178 |
