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Articles Published Processes
4/2/2025 10:54:10 AM | Browse: 18 | Download: 24
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Received |
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2024-11-12 08:21 |
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Peer-Review Started |
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2024-11-12 08:22 |
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To Make the First Decision |
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Return for Revision |
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2025-01-23 03:19 |
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Revised |
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2025-01-26 19:23 |
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Second Decision |
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2025-02-20 02:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-02-20 07:36 |
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Articles in Press |
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2025-02-20 07:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-03-07 06:37 |
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Publish the Manuscript Online |
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2025-04-02 10:54 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Reduced interleukin-2 receptor subunit γ expression in Crohn's disease: A potential mechanism for γδ T cell deficiency
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Md Sadique Hussain, Ajay Singh Bisht and Gaurav Gupta |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Md Sadique Hussain, Assistant Professor, PhD, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Prem Nagar, Dehra Dun 248007, Uttarākhand, India. sadiquehussain007@gmail.com |
| Key Words |
Crohn's disease; Gastrointestinal immunology; Interleukin-2 receptor γ subunit (CD132); Interleukin-7/interleukin-2 signaling pathway; Immune regulation; Immune signaling; T cell apoptosis |
| Core Tip |
Crohn’s disease (CD) is characterized by immune dysregulation, with reduced expression of the interleukin (IL)-2 receptor γ subunit (CD132) playing a pivotal role. CD132 is essential for IL-7/IL-2 signaling, which supports γδ T cell survival and function. Its downregulation impairs immune surveillance, exacerbates γδ T cell deficiency, and contributes to inflammation. This study highlights the therapeutic potential of targeting the IL-7/IL-2 axis to restore immune homeostasis in CD. Future research should explore CD132 modulation as a novel strategy to mitigate γδ T cell dysfunction and improve outcomes for CD patients. |
| Publish Date |
2025-04-02 10:54 |
| Citation |
<p>Hussain MS, Bisht AS, Gupta G. Reduced interleukin-2 receptor subunit γ expression in Crohn's disease: A potential mechanism for γδ T cell deficiency. <i>World J Gastroenterol</i> 2025; 31(13): 103180</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i13/103180.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i13.103180 |
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