| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Shortening the recipient warm ischemia time could be a strategy for expanding the liver donor pool
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia-Wei Yu, Lin-Biao Xiang, Xiao-Juan Dong, Chen-Xi Yang, Lei Wang, Xiao-Yu Liu, Yi-Hong Song, Xian-Jie Bai, Jing-Wen Xiao, Lu Ren, Qin-Hong Xu, Gang-Hua Yang, Yi Lyu and Qiang Lu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Key R&D Plan of Shaanxi Province |
2021GXLH-Z-047 |
|
| Corresponding Author |
Qiang Lu, MD, PhD, National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, No. 76 West Yanta Road, Xi’an 710061, Shaanxi Province, China. luqiang2020@xjtufh.edu.cn |
| Key Words |
Extended criteria donor; Recipient warm ischemia time; Autologous orthotopic liver transplantation; Near-infrared fluorescence imaging; Outcome |
| Core Tip |
Shortening the recipient warm ischemia time (rWIT) can eliminate the negative impact of an extended cold ischemia time. Therefore, this study assessed the effect of shortening the rWIT on the outcomes of liver transplantation using extended-criteria donor (ECD) liver grafts in rats. The fluorescence imaging curve growth rate and postoperative 3-day survival rate significantly increased, and the liver function and Suzuki score of the liver grafts improved when the rWIT was ≤ 10 minutes. Therefore, using ECD liver grafts while shortening the rWIT could be a strategy for expanding the liver donor pool in humans. |
| Publish Date |
2025-02-18 09:00 |
| Citation |
<p>Yu JW, Xiang LB, Dong XJ, Yang CX, Wang L, Liu XY, Song YH, Bai XJ, Xiao JW, Ren L, Xu QH, Yang GH, Lyu Y, Lu Q. Shortening the recipient warm ischemia time could be a strategy for expanding the liver donor pool. <i>World J Gastroenterol</i> 2025; 31(9): 103188</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i9/103188.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i9.103188 |
