| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Natural surgical risks and age distribution in Chinese Peutz-Jeghers syndrome: Real-world research based on web surveys
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Nian-Jun Xiao, Su Liu, Zhe-Yi Han, Tong-Zhen Zhang, Zhi-Meng Jiang, Tao Sun, Jing Zhang, Lei Wang, Shou-Bin Ning and Wen Li |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Wen Li, Chief Physician, MD, PhD, Professor, Medical School of Chinese People’s Liberation Army (PLA), The First Medical Center, Chinese PLA General Hospital, NO.28 Fuxing Road, Haidian District, Beijing City, Beijing 100853, China. wen.li@ufh.com.cn |
| Key Words |
Peutz-Jeghers syndrome; Web surveys; Intussusception; Balloon-assisted enteroscopy; Cumulative risk; Mucocutaneous pigmentation; Hamartomatous polyps |
| Core Tip |
Peutz-Jeghers syndrome (PJS) is a rare disorder characterized by the presence of multiple intestinal polyps, which can lead to intussusception and often require surgery. Screening and preventive intervention for polyps in PJS may reduce the need for surgery. However, most guidelines regarding screening for polyps in PJS are based on expert opinion. This large sample survey demonstrated that patients with PJS exhibit markedly elevated natural surgical risks, particularly between the ages of 6 and 25 years. In light of these findings, we recommend that screening, surveillance, and preventive interventions if indicated, should commence at six years of age. We posit that our strategy based on natural surgical risk is more cost-effective and represents an optimal balance between preventing polyp-related complications and avoiding over-screening. |
| Publish Date |
2025-05-23 08:06 |
| Citation |
<p>Xiao NJ, Liu S, Han ZY, Zhang TZ, Jiang ZM, Sun T, Zhang J, Wang L, Ning SB, Li W. Natural surgical risks and age distribution in Chinese Peutz-Jeghers syndrome: Real-world research based on web surveys. <i>World J Gastrointest Surg</i> 2025; 17(5): 103194</p> |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i5/103194.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i5.103194 |
