Publication Name	World Journal of Nephrology
Manuscript ID	10321
Country	Japan

Received	2014-03-26 14:35
Peer-Review Started	2014-03-26 21:14
To Make the First Decision	2014-04-15 15:18
Return for Revision	2014-04-18 10:30
Revised	2014-05-15 09:03
Second Decision	2014-06-27 17:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-27 17:53
Articles in Press	2014-06-27 18:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-30 17:21
Publish the Manuscript Online	2014-10-19 20:47

ISSN	2220-6124 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Minireviews
Article Title	Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules
Manuscript Source	Invited Manuscript
All Author List	Yoshiyasu Fukusumi, Naoko Miyauchi, Taeko Hashimoto, Akira Saito and Hiroshi Kawachi
Funding Agency and Grant Number
Corresponding Author	Hiroshi Kawachi, MD, PhD, Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-Dori, Niigata 951-8510, Japan. kawachi@med.niigata-u.ac.jp
Key Words	Podocyte; Slit diaphragm; Synaptic vesicle protein 2B; Ephrin-B1; Neurexin
Core Tip	The slit diaphragm located between neighboring foot processes of a glomerular podocyte functions as a final barrier to retain plasma proteins. Recently several molecules such as nephrin and podocin were identified as functional molecules of the slit diaphragm. However, the precise molecular compositions of the slit diaphragm are still unclear and the mechanism regulating its barrier function is not fully understood yet. Recently we have reported that synaptic vesicle protein 2B, ephrin-B1 and neurexin are expressed in podocyte and the decreased function of these molecules participates in the initiation of proteinuria. These molecules could be targets for a novel therapy for proteinuria.
Publish Date	2014-10-19 20:47
Citation	Fukusumi Y, Miyauchi N, Hashimoto T, Saito A, Kawachi H. Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules. World J Nephrol 2014; 3(3): 77-84
URL	http://www.wjgnet.com/2220-6124/full/v3/i3/77.htm
DOI	http://dx.doi.org/10.5527/wjn.v3.i3.77

Full Article (PDF)	WJN-3-77.pdf
Full Article (Word)	WJN-3-77.doc
Manuscript File	10321-Review.docx
Answering Reviewers	10321-Answering reviewers.pdf
Copyright License Agreement	10321-Copyright assignment.pdf
Peer-review Report	10321-Peer review(s).pdf
Scientific Misconduct Check	10321-CrossCheck.jpg
Scientific Editor Work List	10321-Scientific editor work list.pdf