| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Predictive value of tacrolimus concentration/dose ratio in first post-transplant week for CYP3A5-polymorphism in kidney-transplant recipients
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Pham-Thai Dung, Hoang-Xuan Su, Nguyen-Chi Tue, Nguyen-Huu Ben, Nguyen-Minh Phuong, Tuan-Ngoc Tran, Phan-Ba Nghia, Diem-Thi Van, Nguyen Thi-Thuy Dung, Hoang-Trung Vinh, Lionel Rostaing and Pham-Quoc Toan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Vietnam National Foundation for Science and Technology Development |
No. NAFOSTED 04/2020/TN |
|
| Corresponding Author |
Lionel Rostaing, MD, PhD, Professor, Department of Nephrology and Dialysis, Military Hospital, Phung Hung Street, Hanoï 100000, Viet Nam. lrostaing@chu-grenoble.fr |
| Key Words |
Tacrolimus; CYP3A5; Renal transplant recipient; Concentration-to-dose; Kidney transplant |
| Core Tip |
We included in this single-center retrospective study 86 de novo kidney transplant recipients with tacrolimus (TAC)-based immunosuppression. This study aims to evaluate the predictive value of the TAC concentration-to-dose (C0/D) ratio for identifying CYP3A5 polymorphisms within the first week after kidney transplantation. We found that the TAC C0/D ratio provides a reliable predictive value for CYP3A5 polymorphisms, which can be used to individualize TAC dosing in kidney transplant recipients in low-income countries. |
| Publish Date |
2025-02-21 10:12 |
| Citation |
<p>Dung PT, Su HX, Tue NC, Ben NH, Phuong NM, Tran TN, Nghia PB, Van DT, Dung NTT, Vinh HT, Rostaing L, Toan PQ. Predictive value of tacrolimus concentration/dose ratio in first post-transplant week for CYP3A5-polymorphism in kidney-transplant recipients. <i>World J Transplant</i> 2025; 15(2): 103247</p> |
| URL |
https://www.wjgnet.com/2220-3230/full/v15/i2/103247.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v15.i2.103247 |
