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2/20/2025 8:39:54 AM | Browse: 184 | Download: 672
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Received |
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2024-11-18 10:25 |
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Peer-Review Started |
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2024-11-27 09:10 |
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First Decision by Editorial Office Director |
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2024-12-13 08:08 |
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Return for Revision |
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2024-12-13 08:08 |
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Revised |
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2024-12-26 22:25 |
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Publication Fee Transferred |
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2025-01-06 21:38 |
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Second Decision by Editor |
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2025-01-20 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-01-21 09:42 |
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Articles in Press |
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2025-01-21 09:42 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-02-05 09:28 |
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Publish the Manuscript Online |
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2025-02-20 08:39 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Case Report |
| Article Title |
Pathological features of non-alcoholic steatohepatitis in a pediatric patient with heterozygous familial hypobetalipoproteinemia: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kiwako Miyamoto, Sonoko Kondo, Takeo Kondo, Ryou Ishikawa, Ryosuke Tani, Tomoko Inoue, Keiji Matsunaga, Tetsuo Minamino and Takashi Kusaka |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Sonoko Kondo, Assistant Professor, MD, Department of Pediatrics, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Miki 761-0793, Kagawa, Japan. ijichi.sonoko@kagawa-u.ac.jp |
| Key Words |
Nonalcoholic steatohepatitis; Familial hypobetalipoproteinemia; Hypolipidemia; APOB variant; Vitamin E; Case report |
| Core Tip |
This report describes a 12-year-old boy with a prolonged history of liver dysfunction and low levels of low-density lipoprotein cholesterol (LDL-C) who was pathologically diagnosed with nonalcoholic steatohepatitis. His father also had a history of prolonged liver dysfunction and low LDL-C. Genetic testing identified a heterozygous mutation in APOB, which confirmed a diagnosis of familial hypobetalipoproteinemia (FHBL) with nonalcoholic steatohepatitis. Nonalcoholic steatohepatitis is well documented in adults with FHBL. This rare report of FHBL in a child indicates that nonalcoholic steatohepatitis can develop within a relatively short period but responded to treatment with vitamin E. |
| Publish Date |
2025-02-20 08:39 |
| Citation |
Miyamoto K, Kondo S, Kondo T, Ishikawa R, Tani R, Inoue T, Matsunaga K, Minamino T, Kusaka T. Pathological features of non-alcoholic steatohepatitis in a pediatric patient with heterozygous familial hypobetalipoproteinemia: A case report. World J Hepatol 2025; 17(2): 103299 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i2/103299.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i2.103299 |
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