Publication Name	World Journal of Hepatology
Manuscript ID	103299
Country	Japan

Received	2024-11-18 10:25
Peer-Review Started	2024-11-27 09:10
To Make the First Decision
Return for Revision	2024-12-13 08:08
Revised	2024-12-26 22:25
Second Decision	2025-01-20 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-21 09:42
Articles in Press	2025-01-21 09:42
Publication Fee Transferred	2025-01-06 21:38
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-02-05 09:28
Publish the Manuscript Online	2025-02-20 08:39

ISSN	1948-5182 (online)
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Category	Pediatrics
Manuscript Type	Case Report
Article Title	Pathological features of non-alcoholic steatohepatitis in a pediatric patient with heterozygous familial hypobetalipoproteinemia: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Kiwako Miyamoto, Sonoko Kondo, Takeo Kondo, Ryou Ishikawa, Ryosuke Tani, Tomoko Inoue, Keiji Matsunaga, Tetsuo Minamino and Takashi Kusaka
ORCID	Author(s) ORCID Number Sonoko Kondo http://orcid.org/0009-0005-9671-4300
Funding Agency and Grant Number
Corresponding Author	Sonoko Kondo, Assistant Professor, MD, Department of Pediatrics, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Miki 761-0793, Kagawa, Japan. ijichi.sonoko@kagawa-u.ac.jp
Key Words	Nonalcoholic steatohepatitis; Familial hypobetalipoproteinemia; Hypolipidemia; APOB variant; Vitamin E; Case report
Core Tip	This report describes a 12-year-old boy with a prolonged history of liver dysfunction and low levels of low-density lipoprotein cholesterol (LDL-C) who was pathologically diagnosed with nonalcoholic steatohepatitis. His father also had a history of prolonged liver dysfunction and low LDL-C. Genetic testing identified a heterozygous mutation in APOB, which confirmed a diagnosis of familial hypobetalipoproteinemia (FHBL) with nonalcoholic steatohepatitis. Nonalcoholic steatohepatitis is well documented in adults with FHBL. This rare report of FHBL in a child indicates that nonalcoholic steatohepatitis can develop within a relatively short period but responded to treatment with vitamin E.
Publish Date	2025-02-20 08:39
Citation	<p>Miyamoto K, Kondo S, Kondo T, Ishikawa R, Tani R, Inoue T, Matsunaga K, Minamino T, Kusaka T. Pathological features of non-alcoholic steatohepatitis in a pediatric patient with heterozygous familial hypobetalipoproteinemia: A case report. <i>World J Hepatol</i> 2025; 17(2): 103299</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i2/103299.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i2.103299

Full Article (PDF)	WJH-17-103299-with-cover.pdf
CARE Checklist–2016	103299-CARE-Checklist-2016.pdf
Manuscript File	103299_Auto_Edited_141100.docx
Answering Reviewers	103299-answering-reviewers.pdf
Audio Core Tip	103299-audio.mp3
Conflict-of-Interest Disclosure Form	103299-conflict-of-interest-statement.pdf
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Peer-review Report	103299-peer-reviews.pdf
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Scientific Editor Work List	103299-scientific-editor-work-list.pdf
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CrossCheck Report	103299-crosscheck-report.pdf