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Articles Published Processes
4/23/2025 3:33:30 AM | Browse: 46 | Download: 349
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Received |
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2024-11-15 10:38 |
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Peer-Review Started |
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2024-11-15 10:38 |
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First Decision by Editorial Office Director |
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2025-01-24 02:37 |
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Return for Revision |
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2025-01-24 02:37 |
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Revised |
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2025-02-06 00:08 |
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Publication Fee Transferred |
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2025-02-10 03:24 |
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Second Decision by Editor |
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2025-03-14 02:17 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-03-17 08:10 |
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Articles in Press |
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2025-03-17 08:10 |
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Edit the Manuscript by Language Editor |
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2025-03-22 02:30 |
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Typeset the Manuscript |
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2025-04-10 03:33 |
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Publish the Manuscript Online |
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2025-04-23 03:33 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
L-arginine from elder human mesenchymal stem cells induces angiogenesis and enhances therapeutic effects on ischemic heart diseases
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jian-Zhong Li, Xu Zhan, Hao-Bo Sun, Chao Chi, Guo-Fu Zhang, Dong-Hui Liu, Wen-Xi Zhang, Li-Hua Sun and Kai Kang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82472147 |
| Key Research and Development Program of Heilongjiang Province of China |
2023ZX06C04 |
| Open Fund of Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, China |
GPKF202402 |
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| Corresponding Author |
Kai Kang, Department of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Road, Harbin 150000, Heilongjiang Province, China. kangkai1975@sina.com |
| Key Words |
Aging; Angiogenesis; Metabolic; L-arginine; Bone marrow-derived mesenchymal stem cells; Adipose tissue-derived mesenchymal stem cells |
| Core Tip |
This study provided evidence that L-arginine in adipose tissue-derived mesenchymal stem cells (ADSCs) and bone marrow-derived mesenchymal stem cells (BMSCs) from elderly patients with coronary heart disease in serum-free and hypoxic conditions promotes angiogenesis after transplantation to the myocardial infarction (MI) area. ADSCs exhibited the advantages of angiogenesis compared to BMSCs from elderly donors due to higher L-arginine secretion in serum-free and hypoxic conditions. In an animal model of MI, BMSCs in which the arginine succinate lyase gene was integrated had a cardio-protective effect on angiogenesis. These results indicated that ADSCs from elderly patients with coronary heart disease and introduction of L-arginine provide a promising strategy for stem cell therapy after MI. |
| Publish Date |
2025-04-23 03:33 |
| Citation |
Li JZ, Zhan X, Sun HB, Chi C, Zhang GF, Liu DH, Zhang WX, Sun LH, Kang K. L-arginine from elder human mesenchymal stem cells induces angiogenesis and enhances therapeutic effects on ischemic heart diseases. World J Stem Cells 2025; 17(4): 103314 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i4/103314.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i4.103314 |
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