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6/13/2025 1:39:31 PM | Browse: 16 | Download: 60
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 103333
Country United Kingdom
Received
2024-11-18 08:21
Peer-Review Started
2024-11-18 08:21
To Make the First Decision
Return for Revision
2025-02-09 00:16
Revised
2025-02-09 00:59
Second Decision
2025-02-19 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-02-19 05:53
Articles in Press
2025-02-19 05:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-03-05 04:09
Publish the Manuscript Online
2025-06-13 13:39
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Letter to the Editor
Article Title Unravelling the potential of plasma DNA methylation in the detection and surveillance of esophageal cancer
Manuscript Source Invited Manuscript
All Author List Jitesh Arora, Mahmoud Nassar and Bahaaeldin Baraka
ORCID
Author(s) ORCID Number
Mahmoud Nassar http://orcid.org/0000-0002-5401-9562
Bahaaeldin Baraka http://orcid.org/0000-0002-7133-5209
Funding Agency and Grant Number
Corresponding Author Bahaaeldin Baraka, Department of Oncology, Nottingham University Hospitals NHS Trust, Hucknall Rd, Nottingham NG5 1PB, United Kingdom. bahaabaraka@gmail.com
Key Words Esophageal cancer; Plasma DNA methylation; Screening
Core Tip Esophageal cancer (EC) lacks a reliable early detection method, leading to high rates of late-stage diagnosis and poor prognosis. This study explores the use of plasma DNA methylation markers-SHOX2, SEPTIN9, EPO, and RNF180-as a non-invasive tool for early EC screening and surveillance. Demonstrating high sensitivity and specificity, this methylation panel holds promise for improving diagnostic accuracy and patient monitoring. Despite some limitations, this innovative approach could significantly impact clinical practices, offering a transformative solution to enhance early detection, reduce mortality, and improve quality of life for EC patients.
Publish Date 2025-06-13 13:39
Citation <p>Arora J, Nassar M, Baraka B. Unravelling the potential of plasma DNA methylation in the detection and surveillance of esophageal cancer. <i>World J Gastrointest Oncol</i> 2025; 17(6): 103333</p>
URL https://www.wjgnet.com/1948-5204/full/v17/i6/103333.htm
DOI https://dx.doi.org/10.4251/wjgo.v17.i6.103333
Full Article (PDF) WJGO-17-103333-with-cover.pdf
Manuscript File 103333_Auto_Edited_083238.docx
Answering Reviewers 103333-answering-reviewers.pdf
Audio Core Tip 103333-audio.mp3
Conflict-of-Interest Disclosure Form 103333-conflict-of-interest-statement.pdf
Copyright License Agreement 103333-copyright-assignment.pdf
Peer-review Report 103333-peer-reviews.pdf
Scientific Misconduct Check 103333-scientific-misconduct-check.png
Scientific Editor Work List 103333-scientific-editor-work-list.pdf
CrossCheck Report 103333-crosscheck-report.pdf