Publication Name	World Journal of Clinical Cases
Manuscript ID	103372
Country	Japan

Received	2024-11-18 09:59
Peer-Review Started	2024-11-18 09:59
To Make the First Decision
Return for Revision	2025-01-03 08:32
Revised	2025-01-04 00:44
Second Decision	2025-01-13 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-14 13:19
Articles in Press	2025-01-14 13:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-02-06 02:50
Publish the Manuscript Online	2025-02-10 07:51

ISSN	2307-8960 (online)
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Category	Neurosciences
Manuscript Type	Letter to the Editor
Article Title	Challenges in using virtual reality technology for pain relief
Manuscript Source	Invited Manuscript
All Author List	Takahiko Nagamine
ORCID	Author(s) ORCID Number Takahiko Nagamine http://orcid.org/0000-0002-0690-6271
Funding Agency and Grant Number
Corresponding Author	Takahiko Nagamine, MD, PhD, Psychiatric Internal Medicine, Sunlight Brain Research Center, 4-13-18 Jiyugaoka, Hofu 7470066, Yamaguchi, Japan. anagamine@yahoo.co.jp
Key Words	Virtual reality; Acute pain; Chronic pain; Brain network: Medial prefrontal cortex; Dopamine
Core Tip	Two issues were identified as requiring further investigation when using virtual reality (VR) to improve pain. The initial challenge pertains to methodology. It was hypothesized that the effect would be enhanced by incorporating relaxation and biofeedback techniques into the immersive approach. The second challenge pertains to the use of VR for the management of chronic pain. In individuals with chronic pain, there is a reduction in the functionality of the medial prefrontal cortex (mPFC) within the default mode network. The mPFC is closely associated with the reward system and the dopamine nervous system. In the context of chronic pain, it was hypothesized that a program designed to activate the reward system and the dopamine nervous system, utilizing VR, would prove to be an efficacious approach.
Publish Date	2025-02-10 07:51
Citation	<p>Nagamine T. Challenges in using virtual reality technology for pain relief. <i>World J Clin Cases</i> 2025; 13(16): 103372</p>
URL	https://www.wjgnet.com/2307-8960/full/v13/i16/103372.htm
DOI	https://dx.doi.org/10.12998/wjcc.v13.i16.103372

Full Article (PDF)	WJCC-13-103372-with-cover.pdf
Manuscript File	103372_Auto_Edited_074213.docx
Answering Reviewers	103372-answering-reviewers.pdf
Audio Core Tip	103372-audio.mp3
Conflict-of-Interest Disclosure Form	103372-conflict-of-interest-statement.pdf
Copyright License Agreement	103372-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	103372-non-native-speakers.pdf
Peer-review Report	103372-peer-reviews.pdf
Scientific Misconduct Check	103372-scientific-misconduct-check.png
Scientific Editor Work List	103372-scientific-editor-work-list.pdf
CrossCheck Report	103372-crosscheck-report.pdf