Publication Name	World Journal of Gastroenterology
Manuscript ID	103412
Country	China

Received	2024-11-26 06:38
Peer-Review Started	2024-11-26 06:38
To Make the First Decision
Return for Revision	2024-12-18 19:40
Revised	2025-01-10 07:22
Second Decision	2025-02-08 02:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-08 10:55
Articles in Press	2025-02-08 10:55
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-02-12 20:04
Typeset the Manuscript	2025-03-05 02:44
Publish the Manuscript Online	2025-03-13 10:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Inhibition of the SERPINB5/HSP90AA1 axis restrains the proliferation and invasion of rectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Ze-Song Meng, Ji-Tao Hu, Hao Wu and Bao-Kun Li
ORCID	Author(s) ORCID Number Bao-Kun Li http://orcid.org/0009-0005-0906-9965
Funding Agency and Grant Number	Funding Agency Grant Number the Medical Science Research Project Plan of the Hebei Provincial Health Commission 20210027
Corresponding Author	Bao-Kun Li, MD, Second Departments Surgery, The Fourth Hospital of Hebei Medical University, No. 12 Jiankang Road, Shijiazhuang 050011, Hebei Province, China. libaokun@hebmu.edu.cn
Key Words	Rectal cancer; Serpin family B member 5; Heat shock protein 90 alpha class A member 1; Proliferation; Invasion
Core Tip	This study suggested that serpin family B member 5 (SERPINB5) was significantly upregulated in rectal cancer tissues and cell lines. SERPINB5 overexpression increased SW480 cell proliferation and invasion while reducing apoptosis. By contrast, SERPINB5 knockdown had the opposite effects. Moreover, SERPINB5 knockdown retarded the growth of rectal cancer tumors in vivo. Mechanistically, SERPINB5 interacted with heat shock protein 90 alpha family class A member 1 and promoted heat shock protein 90 alpha family class A member 1 expression in SW480 cells.
Publish Date	2025-03-13 10:10
Citation	<p>Meng ZS, Hu JT, Wu H, Li BK. Inhibition of the SERPINB5/HSP90AA1 axis restrains the proliferation and invasion of rectal cancer. <i>World J Gastroenterol</i> 2025; 31(11): 103412</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i11/103412.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i11.103412

Full Article (PDF)	WJG-31-103412-with-cover.pdf
The ARRIVE Guidelines	103412-The-ARRIVE-Guidelines.pdf
Manuscript File	103412_Auto_Edited_054445.docx
Answering Reviewers	103412-answering-reviewers.pdf
Audio Core Tip	103412-audio.mp3
Biostatistics Review Certificate	103412-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	103412-conflict-of-interest-statement.pdf
Copyright License Agreement	103412-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	103412-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	103412-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	103412-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	103412-non-native-speakers.pdf
Peer-review Report	103412-peer-reviews.pdf
Scientific Misconduct Check	103412-scientific-misconduct-check.png
Scientific Editor Work List	103412-scientific-editor-work-list.pdf
CrossCheck Report	103412-crosscheck-report.pdf