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Articles Published Processes
3/13/2025 10:11:01 AM | Browse: 152 | Download: 787
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Received |
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2024-11-25 04:13 |
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Peer-Review Started |
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2024-11-25 04:13 |
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First Decision by Editorial Office Director |
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2024-12-26 23:08 |
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Return for Revision |
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2024-12-26 23:08 |
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Revised |
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2025-01-09 13:06 |
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Publication Fee Transferred |
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2025-01-15 01:01 |
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Second Decision by Editor |
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2025-02-14 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-02-14 05:28 |
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Articles in Press |
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2025-02-14 05:28 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-02-27 06:11 |
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Publish the Manuscript Online |
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2025-03-13 10:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Trichostatin A augments cell migration and epithelial-mesenchymal transition in esophageal squamous cell carcinoma through BRD4/c-Myc endoplasmic reticulum-stress pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Min Chen, Wen-Qian Yang, Ying-Ying Fan, Zhi Chen, Yu-Zhen Liu and Bao-Sheng Zhao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Henan Province Science and Technology Development Plan |
No. 242102311124 |
| Key Medical Scientific and Technological Project of Henan Province |
No. SBGJ202102188 |
| Henan Provincial Medical Science and Technology Project |
No. LHGJ20221012 |
| Fundamental Research Funds for the Universities of Henan Province |
No. NSFRF240308 |
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| Corresponding Author |
Bao-Sheng Zhao, MD, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui 453100, Henan Province, China. drbszhao@xxmu.edu.cn |
| Key Words |
Esophageal squamous cell carcinoma; Histone deacetylase inhibitor; Trichostatin A; Endoplasmic reticulum stress; Epithelial-mesenchymal transition; Cell migration |
| Core Tip |
This study revealed that trichostatin A (TSA), a histone deacetylase inhibitor (HDACi), promoted the migration of esophageal squamous cell carcinoma (ESCC) cells by facilitating epithelial-mesenchymal transition (EMT) through the bromodomain-containing protein (BRD4)/cellular myelocytomatosis oncogene (c-Myc)/endoplasmic reticulum (ER) stress pathway. Mechanistically, TSA-induced histone acetylation enhances BRD4 recruitment and c-Myc expression, which triggers ER stress and subsequently drives EMT. Clinical analyses demonstrated a negative correlation between histone acetylation levels and ESCC prognosis, providing novel insights into the molecular mechanisms of ESCC migration and the implications of HDACi therapy. |
| Publish Date |
2025-03-13 10:11 |
| Citation |
Chen YM, Yang WQ, Fan YY, Chen Z, Liu YZ, Zhao BS. Trichostatin A augments cell migration and epithelial-mesenchymal transition in esophageal squamous cell carcinoma through BRD4/c-Myc endoplasmic reticulum-stress pathway. World J Gastroenterol 2025; 31(11): 103449 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i11/103449.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i11.103449 |
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