| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Longitudinal changes in body composition during palliative systemic chemotherapy and survival outcomes in metastatic colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hyehyun Jeong, Yousun Ko, Kyung Won Kim, Ji Sung Lee, Seyoung Seo, Sun Young Kim, Yong Sang Hong, Jeong Eun Kim and Tae Won Kim |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Korea Health Technology R&D Project through the Korea Health Industry Development Institute, by the Ministry of Health & Welfare, Republic of Korea |
RS-2018-KH049509 |
| the 2022 Cancer Research Support Project from the Korea Foundation for Cancer Research |
CB-2022-A-3 |
|
| Corresponding Author |
Jeong Eun Kim, MD, PhD, Department of Oncology, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea. jeongeunkim@amc.seoul.kr |
| Key Words |
Sarcopenia; Myosteatosis; Obesity; Body composition; Metastatic colorectal cancer; Palliative systemic treatment; Chemotherapy; Deep learning; Artificial intelligence |
| Core Tip |
This retrospective study included a homogeneous group of patients with metastatic colorectal cancer undergoing palliative chemotherapy, monitoring body composition changes through serial computed tomography scans during treatment. The majority of patients experienced changes in body composition, with an increased prevalence of sarcopenia and myosteatosis, both linked to poor survival outcomes. In contrast, visceral and subcutaneous obesity were associated with improved survival. Furthermore, changes in body composition during systemic therapy correlated with end-of-life survival. These findings suggest the prognostic value of monitoring body composition through routine computed tomography scans during chemotherapy. |
| Publish Date |
2025-05-15 10:29 |
| Citation |
<p>Jeong H, Ko Y, Kim KW, Lee JS, Seo S, Kim SY, Hong YS, Kim JE, Kim TW. Longitudinal changes in body composition during palliative systemic chemotherapy and survival outcomes in metastatic colorectal cancer. <i>World J Gastrointest Oncol</i> 2025; 17(5): 103479</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i5/103479.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i5.103479 |
