BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
3/29/2025 6:54:10 AM | Browse: 140 | Download: 557
 |
Received |
|
2024-11-21 06:43 |
|
Peer-Review Started |
|
2024-11-21 06:43 |
|
First Decision by Editorial Office Director |
|
2025-01-08 20:33 |
|
Return for Revision |
|
2025-01-09 14:59 |
|
Revised |
|
2025-01-21 15:27 |
|
Publication Fee Transferred |
|
2025-01-26 05:33 |
|
Second Decision by Editor |
|
2025-02-11 02:36 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2025-02-11 08:15 |
|
Articles in Press |
|
2025-02-11 08:15 |
|
Edit the Manuscript by Language Editor |
|
2025-02-13 07:32 |
|
Typeset the Manuscript |
|
2025-02-20 01:27 |
|
Publish the Manuscript Online |
|
2025-03-29 06:54 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Basic Study |
| Article Title |
Single-nucleus RNA sequencing and spatial transcriptomics reveal the mechanism by which Xiaozhiling injection treats internal hemorrhoids
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Min-Hui Ke, Shu-Yan Huang, Wei-Gan Lin, Zhen-Guo Xu, Xia-Xia Zheng, Xian-Bao Liu, You-Min Cheng and Zuan-Fang Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation Project |
No. 81774118 |
| Foreign Cooperation Project of Science and Technology Department of Fujian Province |
No. 2023I0021 |
| Medical Innovation Project of Fujian Province |
No. 2024CXB013 |
|
| Corresponding Author |
Min-Hui Ke, Department of Proctology, The Second People’s Hospital Affiliated with Fujian University of Traditional Chinese Medicine, No. 282 Wusi Road, Gulou District, Fuzhou 350003, Fujian Province, China. 48330132@qq.com |
| Key Words |
Internal hemorrhoids; Xiaozhiling injection; Fibroblast; Marker gene; Single-cell sequencing; Spatial transcriptome sequencing |
| Core Tip |
Single-cell sequencing revealed differences in the expression and transcription levels of genes collagen 3 alpha 1, decorin, and actin alpha 2 in fibroblasts between control groups and treated groups. The activation of fibroblasts and the expression of key genes in the sphingosine kinase 1-sphingosine-1-phosphate pathway were observed at the injection site, suggesting that the sphingosine kinase 1-sphingosine-1-phosphate pathway could be activated to promote fibrosis after the intervention of Xiaozhling. |
| Publish Date |
2025-03-29 06:54 |
| Citation |
Ke MH, Huang SY, Lin WG, Xu ZG, Zheng XX, Liu XB, Cheng YM, Li ZF. Single-nucleus RNA sequencing and spatial transcriptomics reveal the mechanism by which Xiaozhiling injection treats internal hemorrhoids. World J Gastrointest Surg 2025; 17(4): 103494 |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i4/103494.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i4.103494 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
