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11/17/2014 3:13:00 PM | Browse: 780 | Download: 1099
Publication Name World Journal of Gastroenterology
Manuscript ID 10351
Country/Territory China
Received
2014-03-31 11:28
Peer-Review Started
2014-03-31 15:06
To Make the First Decision
2014-05-29 19:07
Return for Revision
2014-06-03 18:15
Revised
2014-06-10 15:52
Second Decision
2014-07-22 16:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-07-22 17:15
Articles in Press
2014-07-22 18:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-08-07 10:44
Typeset the Manuscript
2014-11-11 17:02
Publish the Manuscript Online
2014-11-17 15:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Increased expression and possible role of chitinase 3-like-1 in a colitis-associated carcinoma model
Manuscript Source Unsolicited Manuscript
All Author List Jia-Yi Ma, Run-Hua Li, Kun Huang, Gao Tan, Chen Li and Fa-Chao Zhi
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81170341
Corresponding Author Fa-Chao Zhi, MD, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Road, Guangzhou 510515, Guangdong Province, China. zhifc41532@163.com
Key Words Inflammatory bowel disease; Ulcerative colitis; Colitis-associated carcinoma; Murine model; Chitinase 3-like-1; Oxidative stress; Colorectal cancer
Core Tip Increased expression of chitinase 3-like-1 (CHI3L1) mRNA was found in ulcerative colitis patients with dysplasia. It is not known whether CHI3L1 contributes to inflammation-driven carcinogenesis. Our study showed increased expression of CHI3L1 during the progression of carcinogenesis. Caffeine protected against severe inflammation and neoplasms by acting as a scavenger of reactive oxygen species (ROS), which may be partly attributed to CHI3L1 inhibition. In vitro data showed that CHI3L1 increased ROS production in colonic epithelial cells under conditions of oxidative stress. Our study has made a modest advance in the exploration of CHI3L1 in colitis-associated carcinoma.
Publish Date 2014-11-17 15:12
Citation Ma JY, Li RH, Huang K, Tan G, Li C, Zhi FC. Increased expression and possible role of chitinase 3-like-1 in a colitis-associated carcinoma model. World J Gastroenterol 2014; 20(42): 15736-15744
URL http://www.wjgnet.com/1007-9327/full/v20/i42/15736.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i42.15736
Full Article (PDF) WJG-20-15736.pdf
Full Article (Word) WJG-20-15736.doc
Manuscript File 10351-Review.doc
Answering Reviewers 10351-Answering reviewers.pdf
Copyright License Agreement 10351-Copyright assignment.pdf
Institutional Review Board Approval Form or Document Ethics_Committee_20140327144932.doc
Non-Native Speakers of English Editing Certificate 10351-Language certificate.PDF
Peer-review Report 10351-Peer review(s).pdf
Scientific Misconduct Check 10351-CrossCheck.jpg
Scientific Editor Work List 10351-Scientific editor work list.pdf