Publication Name	World Journal of Gastroenterology
Manuscript ID	10351
Country	China

Received	2014-03-31 11:28
Peer-Review Started	2014-03-31 15:06
To Make the First Decision	2014-05-29 19:07
Return for Revision	2014-06-03 18:15
Revised	2014-06-10 15:52
Second Decision	2014-07-22 16:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-22 17:15
Articles in Press	2014-07-22 18:31
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-08-07 10:44
Typeset the Manuscript	2014-11-11 17:02
Publish the Manuscript Online	2014-11-17 15:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Increased expression and possible role of chitinase 3-like-1 in a colitis-associated carcinoma model
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Yi Ma, Run-Hua Li, Kun Huang, Gao Tan, Chen Li and Fa-Chao Zhi
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81170341
Corresponding Author	Fa-Chao Zhi, MD, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Road, Guangzhou 510515, Guangdong Province, China. zhifc41532@163.com
Key Words	Inflammatory bowel disease; Ulcerative colitis; Colitis-associated carcinoma; Murine model; Chitinase 3-like-1; Oxidative stress; Colorectal cancer
Core Tip	Increased expression of chitinase 3-like-1 (CHI3L1) mRNA was found in ulcerative colitis patients with dysplasia. It is not known whether CHI3L1 contributes to inflammation-driven carcinogenesis. Our study showed increased expression of CHI3L1 during the progression of carcinogenesis. Caffeine protected against severe inflammation and neoplasms by acting as a scavenger of reactive oxygen species (ROS), which may be partly attributed to CHI3L1 inhibition. In vitro data showed that CHI3L1 increased ROS production in colonic epithelial cells under conditions of oxidative stress. Our study has made a modest advance in the exploration of CHI3L1 in colitis-associated carcinoma.
Publish Date	2014-11-17 15:12
Citation	Ma JY, Li RH, Huang K, Tan G, Li C, Zhi FC. Increased expression and possible role of chitinase 3-like-1 in a colitis-associated carcinoma model. World J Gastroenterol 2014; 20(42): 15736-15744
URL	http://www.wjgnet.com/1007-9327/full/v20/i42/15736.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i42.15736

Full Article (PDF)	WJG-20-15736.pdf
Full Article (Word)	WJG-20-15736.doc
Manuscript File	10351-Review.doc
Answering Reviewers	10351-Answering reviewers.pdf
Copyright License Agreement	10351-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140327144932.doc
Non-Native Speakers of English Editing Certificate	10351-Language certificate.PDF
Peer-review Report	10351-Peer review(s).pdf
Scientific Misconduct Check	10351-CrossCheck.jpg
Scientific Editor Work List	10351-Scientific editor work list.pdf