| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Basic Study |
| Article Title |
Shenzhuo formulation ameliorates diabetic nephropathy by regulating cytochrome P450-mediated arachidonic acid metabolism
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhong-Yong Zhang, Yu-Ming Wang, Ning Wang, Yuan-Song Wang, Hui Zhang, Duo Wang, Li-Xin Wang, Huan-Tian Cui, Wei-Bo Wen, Shu-Quan Lv and Yong-Jun Cao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Natural Science Foundation of Hebei Province Beijing-Tianjin-Hebei Basic Research Special Program |
H2020110287 |
| Key Laboratory for Diabetic Kidney Disease Syndrome and Treatment of the Traditional Chinese Medicine Administration of Hebei Province |
7 [2024] |
| Yuansong Wang National Famous Traditional Chinese Medicine Expert Heritage Studio |
3 [2024] |
| Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine for Diabetes and Its Complications |
SZX2020015 |
| Jiangsu Province Chinese Medicine Science and Technology Development Program Project |
YB2020065 |
|
| Corresponding Author |
Shu-Quan Lv, Chief Physician, PhD, Department of Endocrinology, Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese Medicine, No. 5 Xianghai Road, High-tech Zone, Cangzhou 061012, Hebei Province, China. czlvshuquan@163.com |
| Key Words |
Diabetic nephropathy; Shenzhuo formulation; Transcriptomic; Metabolomic; Cytochrome P450; Arachidonic acid metabolic; Inflammatory; Oxidative stress |
| Core Tip |
This study aimed to evaluate the therapeutic impact of Shenzhuo formulation (SZF) on a diabetic nephropathy (DN) mouse model and to examine its potential molecular mechanisms using transcriptomic and metabolomic approaches. The findings of this research substantiated the significant potential of SZF in ameliorating renal injury in DN mice. The primary pathway through which SZF mitigates renal injury appears to be the modulation of cytochrome P450-mediated AA metabolism, which contributes to its anti-inflammatory and antioxidant effects. |
| Publish Date |
2025-04-25 07:53 |
| Citation |
<p>Zhang ZY, Wang YM, Wang N, Wang YS, Zhang H, Wang D, Wang LX, Cui HT, Wen WB, Lv SQ, Cao YJ. Shenzhuo formulation ameliorates diabetic nephropathy by regulating cytochrome P450-mediated arachidonic acid metabolism. <i>World J Diabetes</i> 2025; 16(5): 103511</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i5/103511.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i5.103511 |
